Expanding on their previous Mendelian Randomisation study (CIRCULATION 2019) ISD researchers now provide further evidence for a causal role of MCP-1 in stroke. In a meta-analysis of observational data from 17,180 stroke-free individuals they found higher circulating MCP-1 levels to be associated with long-term risk of incident ischemic stroke.
Using a prospective, high-frequency serial imaging study, a team of researchers at ISD and Radboudumc Nijmegen identified acute infarcts as the cause of incident lacunes and almost a third of incident microbleeds. In contrast, the progression of white matter hyperintensities was independent from acute infarcts. These new insights were enabled through a unique study design with monthly MRI exams [more]
ISD Research Retreat
July 10th and 11th ISD research teams met for the yearly scientific retreat to present their projects and discuss the science. At the heart of this meeting were presentations from all Ph.D. students, including an evning poster session. The last year brought about important achievements both scientifically and with regard to expertise and infrastructure. The meeting further served as an opportunity to familiarize people with the medium- and
long-term strategy of ISD.
The project led by Christian Grimm (Walther‐Straub‐Institute) and Dominik Paquet (ISD) is supported with 86.000 Euros by the German Neuronal Ceroid Lipofuscinosis Foundation (NCL) and aims to develop novel treatment strategies for childhood dementia. [read more]
A multinational study led by Michael Ewers and his team suggests that enhanced tau pathology may underlie the increased risk of Alzheimer’s conferred by the BIN1 single nucleotide polymorphism - the second most important genetic risk factor of AD. [read more]
Congratulations to our longstanding collaborators Marie-Germain Bousser, Anne Joutel, Hugues Chabriat, & Elisabeth Tournier-Lasserve (Paris, Fr.) for receiving the prestigious BRAIN price. Their groundbreaking work on CADASIL has profoundly influenced the understanding of cerebral small vessel disease & vascular cognitive impairment... [read more]
A combined fMRI and tau PET study in Alzheimer’s disease by Michael Ewers and team shows that the spatial pattern of tau pathology is predicted by functional network connectivity, suggesting that cross-talk between brain regions is conducive to tau spreading... [read more]
The Erturk group developed a nanobody-based immunolabeling method, vDISCO, that enables imaging subcellular details in transparent mice. They uncovered neuronal projections and skull–meninges connections in whole adult mice that are likely to have relevance in both health and disease... [read more]
A genome-wide meta-analysis involving almost 900.00 subjects from the MEGASTROKE consortium and UK Biobank identified new risk loci for stroke among them endothelial nitric oxide synthase (NOS3). The study further suggests that genetic variation in the NOS - nitric oxide (NO) pathway in part affects stroke risk via variation in blood pressure... [read more]
ISD investigators in collaboration with researchers from France found that MoCA, a brief cognitive test, when taken within a week after stroke predicts the risk of cognitive impairment, functional impairment and mortality up to 3 years later. The findings inform clinical practice by highlighting the need of early cognitive screening after stroke... [read more]
Using a Mendelian Randomization approach and data from >800.000 individuals ISD investigators showed that genetic predisposition to higher levels of the inflammatory cytokine MCP-1 is associated with a higher risk of stroke, in particular large artery stroke and cardioembolic stroke. These findings inform the planning of future clinical trials... [read more]
The first funding decisions in the context of the Excellence Strategy have been announced. Four Clusters of Excellence including the Munich Cluster for Systems Neurology (SyNergy) submitted by LMU and TUM were successful and will receive funding from 2019 on...[read more]
Chenchen Pan from Ali Ertuerk's group received the Chinese government award for outstanding self-finance students abroad. Established by the China Scholarship Council in 2003 the award is considered the highest recognition given by the Chinese government to graduate students abroad who do not receive financial support from the Chinese government...[read more]
A prestigious ERC Starting Grant was awarded to the ISD researcher Arthur Liesz for the project „RecoverInFlame“. The 1.5M € award by the European Research Council (ERC) will support the Liesz lab to investigate inflammatory mechanisms in the recovery after acute stroke...[read more]
Stefan Roth and Dr. Arthur Liesz were awarded with the "Rolf-Becker"-Prize for one of the best scientific outputs in 2017/18 by the Medical Faculty of LMU Munich and the foundation "Rufzeichen Gesundheit!" Baierbrunn. They received this prestigious award for their recent work published in Science Translational Medicine...
A large scale genetic study on major brain diseases including stroke and Alzheimer's disease revealed shared genetic influences between multiple brain disorders and relevant phenotypes, including cognitive measures. The results highlight the value of heritability-based methods in understanding the ethiology of neurological and psychiatric disorders. ISD investigators were on the steering committee of this work which was published in Science...
The Collaborative Research Center SFB1123 „Atherosclerosis – Mechanisms and Networks of Novel Therapeutic Targets" has been approved a second funding period. The ISD contributes to the LMU led network with two projects, headed by Martin Dichgans/Yaw Asare (project B5) and Jürgen Bernhagen (project A3), as well as flanking project C1 (Arthur Liesz)...
Complex heart surgery may lead to organ dysfunction such as acute kidney injury (AKI) or ischemic stroke. A researcher team led by Aachen University and the Bernhagen lab found that patients with high blood levels of the cytokine MIF had a reduced risk of developing AKI. The study is published in this week’s issue of Sci Transl Med...
Isolation of CADASIL patient brain vessels in combination with proteome analysis identified loss of HTRA1 proteolytic function as a critical step in the development of disease pathology providing novel insights into the molecular mechanisms of cerebral small vessel diseases....
Munich, March 21-23, the European Stroke Organisation (ESO) in collaboration with the Stroke Alliance for Europe (SAFE) convened leading experts in stroke research and care to an international workshop targeted at identifying current challenges in the prevention and treatment of stroke, set the goals for the next decade...