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                                              3. Simons Lab

                                              Mikael Simons – Biology of Glia and Neuro­inflammation

                                              • Research Focus
                                              • Publications
                                              • Team
                                              • The PI

                                              Glia are essential for the function of the nervous system. We study how glial cells contribute to brain function and how their dysfunction leads to diseases. Our research ranges from functions of glia during nervous system development and maintenance to their role in aging, neurodegenerative and inflammatory diseases. One focus is on myelin, an insulating membrane sheath produced by oligodendrocytes in the central nervous system. Destruction of myelin leads is a pathological hallmark of multiple sclerosis, but is also associated with several neurodegenerative disorders. Another focus is on the biology of microglia, and their functions in regenerative and degenerative processes. Our lab combines genetic, molecular, biochemical and advanced light and electron microscopy techniques to study how glia operate in health and disease.

                                              The lab is part of the Institute of Neuronal Cell Biology, belongs to the TUM Faculty of Medicine, and is affiliated with the German Center for Neurodegenerative Diseases and the Institute for Stroke and Dementia Research. Our lab is located at the Center of Stroke and Dementia Research at Campus Grosshadern in Munich.

                                              For more information:

                                              Simons Lab

                                              Contact:

                                              Prof. Dr. Mikael Simons

                                              Phone: +49-(0)89 440046495

                                              Email: mikael.simons@dzne.de; m.simons@tum.de

                                              Key Publications

                                              >All Publications

                                              Safaiyan S*, Besson-Girard S*, Kaya T, Cantuti-Castelvetri L, Liu L, Ji H, Schifferer M, Gouna G, Usifo F, Kannaiyan N, Fitzner D, Xiang X, Rossner MJ, Brendel M, Gokce O, Simons M*. White matter aging drives microglial diversity. Neuron. 2021 Apr 7;109(7):1100-1117.e10. doi: 10.1016/j.neuron.2021.01.027. Epub 2021 Feb 18. 

                                              Bosch-Queralt M, Cantuti-Castelvetri L, Damkou A, Schifferer M, Schlepckow K, Alexopoulos I, Lütjohann D, Klose C, Vaculčiaková L, Masuda T, Prinz M, Monroe KM, Di Paolo G, Lewcock JW, Haass C, Simons M. Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Nat Metab. 2021 Feb;3(2):211-227. doi: 10.1038/s42255-021-00341-7. Epub 2021 Feb 18. 

                                              Cantuti-Castelvetri L*, Ojha R*, Pedro LD, Djannatian M*, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu T, Hepojoki J, Vapalahti O, Stadelmann C, Balistreri G*, Simons M. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science. 2020 Nov 13;370(6518):856-860. doi: 10.1126/science.abd2985. Epub 2020 Oct 20. 

                                              Mukherjee C*, Kling T*, Russo B, Miebach K, Kess E, Schifferer M, Pedro LD, Weikert U, Fard MK, Kannaiyan N, Rossner M, Aicher ML, Goebbels S, Nave KA, Krämer-Albers EM, Schneider A*, Simons M*. Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Cell Metab. 2020 Aug 4;32(2):259-272.e10. doi: 10.1016/j.cmet.2020.05.019. Epub 2020 Jun 11. 

                                              Cantuti-Castelvetri L*, Fitzner D*, Bosch-Queralt M, Weil MT, Su M, Sen P, Ruhwedel T, Mitkovski M, Trendelenburg G, Lütjohann D, Möbius W, Simons M. Defective cholesterol clearance limits remyelination in the aged central nervous system. Science. 2018 Feb 9;359(6376):684-688. doi: 10.1126/science.aan4183. Epub 2018 Jan 4. 

                                              Fard MK, van der Meer F, Sánchez P, Cantuti-Castelvetri L, Mandad S, Jäkel S, Fornasiero EF, Schmitt S, Ehrlich M, Starost L, Kuhlmann T, Sergiou C, Schultz V, Wrzos C, Brück W, Urlaub H, Dimou L, Stadelmann C, Simons M. BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions. Sci Transl Med. 2017 Dec 6;9(419):eaam7816. doi: 10.1126/scitranslmed.aam7816.

                                              Fard MK, van der Meer F, Sánchez P, Cantuti-Castelvetri L, Mandad S, Jäkel S, Fornasiero EF, Schmitt S, Ehrlich M, Starost L, Kuhlmann T, Sergiou C, Schultz V, Wrzos C, Brück W, Urlaub H, Dimou L, Stadelmann C, Simons M. BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions. Sci Transl Med. 2017 Dec 6;9(419):eaam7816. doi: 10.1126/scitranslmed.aam7816.

                                              Safaiyan S, Kannaiyan N, Snaidero N, Brioschi S, Biber K, Yona S, Edinger AL, Jung S, Rossner MJ, Simons M. Age-related myelin degradation burdens the clearance function of microglia during aging. Nat Neurosci. 2016 Aug;19(8):995-8. doi: 10.1038/nn.4325. Epub 2016 Jun 13. 

                                              Sharma K, Schmitt S, Bergner CG, Tyanova S, Kannaiyan N, Manrique-Hoyos N, Kongi K, Cantuti L, Hanisch UK, Philips MA, Rossner MJ, Mann M, Simons M. Cell type- and brain region-resolved mouse brain proteome. Nat Neurosci. 2015 Dec;18(12):1819-31. doi: 10.1038/nn.4160. Epub 2015 Nov 2. 

                                              Snaidero N, Möbius W, Czopka T, Hekking LH, Mathisen C, Verkleij D, Goebbels S, Edgar J, Merkler D, Lyons DA, Nave KA, Simons M. Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell. 2014 Jan 16;156(1-2):277-90. doi: 10.1016/j.cell.2013.11.044. 

                                              Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B, Simons M. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science. 2008 Feb 29;319(5867):1244-7. doi: 10.1126/science.1153124. 

                                              Prof. Dr. med. Mikael Simons, Group leader

                                              Jana Salovic, Assistant

                                              Dr. Stefan Berghoff, PostDoc

                                              Dr. Ludovico Cantuti-Castelvetri, PostDoc

                                              Dr. med. Minou Djannatian, PostDoc

                                              Dr. Seiji Kaji, PostDoc

                                              Dr. med Johanna Knoeferle, PostDoc

                                              Alkmini Damkou, PhD student

                                              Liliana Pedro Domingues, PhD student

                                              Garyfallia Gouna, PhD student

                                              Tugberk Kaya, PhD student

                                              Shreeya Kedia, PhD student

                                              Swathi Radha, PhD student

                                              Lennart Schlaphoff, PhD student

                                              Vini Tiwari, PhD student

                                              Martin Zirngibl, PhD student

                                              Jianping Wu, PhD student

                                              Agata Rhomberg, Technician

                                              Tommaso Di Genio, Master student

                                              Simona Vitale, Master student

                                              Cansu Üstüner, Master student

                                              Mikael Simons

                                              Mikael Simons

                                              Professor of Molecular Neuroscience

                                              Institute of Neuronal Cell Biology (TUM-NCB)

                                              Technical University Munich
German Center for Neurodegenerative Diseases (DZNE)

                                              Institute for Stroke and Dementia Research (ISD)

                                              Feodor-Lynen-Straße 17

                                              81377 Munich, Germany

                                              Telefon: +49-(0)89 440046495

                                              Email:
 mikael.simons@dzne.de; 
m.simons@tum.de



                                              Scientific vita

                                              2016 – present: W3- Professorship and Director, Institute of Neuronal Cell Biology, TU Munich, Germany

                                              2020 – present: Head of Clinical Research & Clinical Trial Unit Munich at the German Centre for Neurodegenerative Diseases in Munich (DZNE/Munich)

                                              2016 – present: Group leader at the German Centre for Neurodegenerative Diseases in Munich (DZNE/Munich)

                                              2022 – present: Group leader at the Institute for Stroke and Dementia Research (ISD)

                                              Since 2004: Board Certificate in Neurology, Department of Neurology, University of Tübingen


                                              Coordinating Functions

                                              2016 – present: Member of the Medical Faculty of the TU Munich

                                              2016 – present: Board member, Munich Cluster for Systems Neurology (SyNergy)

                                              2016 – present: Speaker of the Collaborative Research Centre (TRR 274)

                                              2018 – present: Member of the Graduate School of Systems Neuroscience

                                              2020 – present: Member of the steering board of Clinical Research at the TUM (KKF)

                                              2016 – present: Co-head of the electron microscopy hub of SyNergy

                                              2020 – present: Co-head of the single genomics hub of the Collaborative Research Center 274


                                              Contact

                                              Institute for Stroke and Dementia Research (ISD)
                                              University Hospital, LMU Munich

                                              Director: Prof. Dr. med. Martin Dichgans

                                              Feodor-Lynen-Straße 17
                                              81377 Munich, Germany

                                              Phone: +49 (0)89 4400 46019
                                              www.isd-research.de
                                              Send a Mail

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                                              Neurologische Klinik und Poliklinik der Universität München

                                              DZNE – Deutsches Zentrum für Neurodegenerative Erkrankungen

                                              SyNergy – Munich Cluster for Systems Neurology

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