Georgakis Lab News

Genetic Architecture of Circulating Cytokine Levels. 

May 2024 – New lab preprint on the genetic architecture of circulating cytokine levels. By analyzing genomic data for 40 cytokines from >70,000 individuals, we were able to detect 169 genomic signals, four of which pointed to key targets for the development of novel tailored immunotherapies against autoimmune disease. The GWAS data were made freely available to the research community. The work represents part of the doctoral thesis of Marek Konieczny. Congratulations Marek!

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Murad Omarov presenting his work at the meeting of the International Stroke Genetic Consortium (ISGC). 

April 2024 – Murad presented his work on deep learning analyses of carotid ultrasound images at the ISGC meeting in Munich. 

Role of CXCL10 as a causal mediator in Atherosclerosis. 

February 2024 – Integrating genetic information from >520,000 individuals with data from plasma proteomics, the team of Marios Georgakis identified a proteomic signature of IL-6 signaling activation and mediators of its effects on cardiovascular disease. Their analyses suggest, that the interferon-γ-inducible chemokine CXCL10 is a potentially causal mediator for atherosclerosis in different vascular beds (coronary, cerebral, and peripheral arteries) and could serve as a promising drug target for atheroprotection. 

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