Research Groups

The gut microbiome has been reproducibly demonstrated to play a pivotal role in brain health and brain disease. Recent experimental and clinical studies suggest that stroke outcome is substantially impacted by the composition of the gut microbiome... [read more]

Alzheimer’s disease is characterized by the accumulation of cerebral beta-amyloid (Aβ) and tau pathology, which together cause progressive neurodegeneration and cognitive decline.

Changes in the genome, called mutations, are the driving force of evolution. These mutations continue to shape us from the moment we begin life as a single cell to the end of our life by altering the genome of each cell. During development, these somatic mutations provide important benefits including fighting infections

We are interested in the role of oligodendrocytes – the myelin forming cells in the central nervous system – in Alzheimer’s disease. For decades, the pathology in Alzheimer’s has been considered purely neuronal, however, recent advances have clearly demonstrated glial involvement, initiating a shift in scientific focus...

We aim to identify circulating signatures that inform on the local and systemic effects of stroke and to explore the underlying molecular and pathophysiological mechanisms. Events in most organs including the local and systemic events (e.g. stress) related to acute stroke are captured by the circulating proteome and metabolome...