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Scientific Advisory Board
Diversity at the ISD
Translational Research – Martin Dichgans
We are interested in the molecular, cellular, and physiological mechanisms of stroke and cerebrovascular disease. We use genetic approaches to identify novel risk genes and explore their functional role in vitro and in vivo […]
Vascular Biology – Jürgen Bernhagen
We are interested in the molecular and cellular mechanisms of cardiovascular disease and inflammation. A focus is on the role of atypical chemokines, inflammatory signaling pathways, and leukocyte recruitment processes in atherosclerosis […]
Vascular Cognitive Impairment – Marco Düring
We are interested in the mechanisms by which vascular dysfunction causes cognitive decline. The major focus of our work is on cerebral small vessel disease (SVD), the most common cause of […]
Acute Brain Injury – Ali Erturk
A fundamental challenge in modern science is to understand how the brain functions in health and what goes wrong in the disease state. We develop and implement 3D imaging technologies to be able to generate the highest resolution views of intact rodent organs and bodies... [read more]
Brain Imaging & Biomarker – Michael Ewers
We are interested in the detection of brain changes that precede the manifestation of dementia symptoms in Alzheimer’s disease. The first major focus is the detection of protective brain mechanisms that delay the onset of cognitive impairmen […]
Stroke-Immunology – Arthur Liesz
We are interested in the interplay between the brain and the immune system after stroke. Acute brain lesions disturb the well-balanced interconnection between both systems. Hence, our research focuses on both directions of brain-immune ...[read more]
Neurodegeneration and Vascular Dysfunction – Dominik Paquet
The PaquetLab aims to understand the molecular and cellular mechanisms leading to nerve cell death and cognitive decline in patients with neuropsychiatric disorders (e.g. Alzheimer’s disease, Frontotemporal dementia and related disorders) and neurovascular impairments... [read more]
Experimental Stroke Research – Nick Plesnila
The main interest of the laboratory is to study the role of cerebral vessels for the pathophysiology of acute and chronic brain injury and to use the evolving knowledge for the development of novel therapeutic strategies for patients... [read more]
Junior Research Groups
Microbiome-gut-brain interactions – Corinne Benakis
The gut microbiome has been reproducibly demonstrated to play a pivotal role in brain health and brain disease. Recent experimental and clinical studies suggest that stroke outcome is substantially impacted by the composition of the gut microbiome... [read more]
Alzheimer’s Disease Neuroimaging – Nicolai Franzmeier
Alzheimer’s disease is characterized by the accumulation of cerebral beta-amyloid (Aβ) and tau pathology, which together cause progressive neurodegeneration and cognitive decline.
Systems Neuroscience – Ozgun Gokce
Changes in the genome, called mutations, are the driving force of evolution. These mutations continue to shape us from the moment we begin life as a single cell to the end of our life by altering the genome of each cell. During development, these somatic mutations provide important benefits including fighting infections
Oligodendrocyte Pathology – Sarah Jäkel
We are interested in the role of oligodendrocytes – the myelin forming cells in the central nervous system – in Alzheimer’s disease. For decades, the pathology in Alzheimer’s has been considered purely neuronal, however, recent advances have clearly demonstrated glial involvement, initiating a shift in scientific focus...
Molecular Biomarkers – Steffen Tiedt
We aim to identify circulating signatures that inform on the local and systemic effects of stroke and to explore the underlying molecular and pathophysiological mechanisms. Events in most organs including the local and systemic events (e.g. stress) related to acute stroke are captured by the circulating proteome and metabolome...