Marco Duering – Vascular Cognitive Impairment

Research Focus
Publications
Lab

We are interested in the mechanisms by which vascular dysfunction causes cognitive decline. The major focus of our work is on cerebral small vessel disease (SVD), the most common cause of vascular cognitive impairment (VCI) and also a frequent finding in patients with neurodegenerative disease including Alzheimer’s disease.

Our methodological expertise is in structural and functional neuroimaging in humans using advanced analytical and statistical techniques.

We use datasets from large cohorts including population-based samples as well as patients with stroke and genetically defined forms of SVD. A specific focus of our group is on CADASIL, an inherited form of SVD and model disease for pure VCI.

A major theme is the development of biomarkers for VCI. We recently established a novel, fully automated and robust biomarker based on diffusion tensor imaging. A toolbox for the calculation of this novel biomarker is available publicly: www.psmd-marker.com

Another focus of our work is on the interplay between vascular and neurodegenerative pathology. Thus, for example, our group recently revealed a link between subcortical infarcts and changes of cortical morphology implying a role for remote, secondary neurodegeneration in stroke and VCI.

Contact: Prof. Dr. med. Marco Düring
Tel: +49-89-4400-46166
marco.duering@med.uni-muenchen.de

Publications by Marco Düring

Key Publications

All Publications

2021

Dewenter A, Gesierich B, Ter Telgte A, Wiegertjes K, Cai M, Jacob MA, Marques JP, Norris DG, Franzmeier N, de Leeuw FE, Tuladhar AM, Duering M. Systematic validation of structural brain networks in cerebral small vessel disease. J Cereb Blood Flow Metab. 2021 Dec 20:271678X211069228. doi: 10.1177/0271678X211069228. Epub ahead of print.

2020

Konieczny MJ, Dewenter A, Telgte AT, Gesierich B, Wiegertjes K, Finsterwalder S, Kopczak A, Hübner M, Malik R, Tuladhar AM, Marques JP, Norris DG, Koch A, Dietrich O, Ewers M, Schmidt R, de Leeuw FE, Duering M. Multi-shell diffusion MRI models for white matter characterization in cerebral small vessel disease. Neurology. 2020 Nov 16;10.1212/WNL.0000000000011213.

Finsterwalder S, Vlegels N, Gesierich B, Araque Caballero MÁ, Weaver NA, Franzmeier N, Georgakis MK, Konieczny MJ, Koek HL; Dominantly Inherited Alzheimer Network (DIAN), Karch CM, Graff-Radford NR, Salloway S, Oh H, Allegri RF, Chhatwal JP; DELCODE study group, Jessen F, Düzel E, Dobisch L, Metzger C, Peters O, Incesoy EI, Priller J, Spruth EJ, Schneider A, Fließbach K, Buerger K, Janowitz D, Teipel SJ, Kilimann I, Laske C, Buchmann M, Heneka MT, Brosseron F, Spottke A, Roy N, Ertl-Wagner B, Scheffler K; Alzheimer's Disease Neuroimaging Initiative (ADNI); Utrecht VCI study group, Seo SW, Kim Y, Na DL, Kim HJ, Jang H, Ewers M, Levin J, Schmidt R, Pasternak O, Dichgans M, Biessels GJ, Duering M. Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients. Alzheimers Dement. 2020 Nov;16(11):1504-1514.

2019

Ter Telgte A, Wiegertjes K, Gesierich B, Marques JP, Huebner M, de Klerk JJ, Schreuder FHBM, Araque Caballero MA, Kuijf HJ, Norris DG, Klijn CJM, Dichgans M, Tuladhar AM, Duering M, de Leeuw FE. Contribution of acute infarcts to cerebral small vessel disease progression. Ann Neurol. 2019 Oct;86(4):582-592.

2018

Duering M, Finsterwalder S, Baykara E, Tuladhar AM, Gesierich B, Konieczny MJ, Malik R, Franzmeier N, Ewers M, Jouvent E, Biessels GJ, Schmidt R, de Leeuw FE, Pasternak O, Dichgans M. Free water determines diffusion alterations and clinical status in cerebral small vessel disease. Alzheimers Dement. 2018 Jun;14(6):764-774.

2017

Wollenweber FA, Baykara E, Zedde M, Gesierich B, Achmüller M, Jouvent E, Viswanathan A, Ropele S, Chabriat H, Schmidt R, Opherk C, Dichgans M, Linn J, Duering M. Cortical Superficial Siderosis in Different Types of Cerebral Small Vessel Disease. Stroke. 2017 May;48(5):1404-1407.

Duering M, Schmidt R. Remote changes after ischaemic infarcts: a distant target for therapy? Brain. 2017 Jul 1;140(7):1818-1820.

2016

Baykara E, Gesierich B, Adam R, Tuladhar AM, Biesbroek JM, Koek HL, Ropele S, Jouvent E; Alzheimer's Disease Neuroimaging Initiative, Chabriat H, Ertl-Wagner B, Ewers M, Schmidt R, de Leeuw FE, Biessels GJ, Dichgans M, Duering M. A Novel Imaging Marker for Small Vessel Disease Based on Skeletonization of White Matter Tracts and Diffusion Histograms. Ann Neurol. 2016 Oct;80(4):581-92.

Gesierich B, Duchesnay E, Jouvent E, Chabriat H, Schmidt R, Mangin JF, Duering M, Dichgans M. Features and Determinants of Lacune Shape: Relationship With Fiber Tracts and Perforating Arteries. Stroke. 2016 May;47(5):1258-64.

2015

Duering M, Righart R, Wollenweber FA, Zietemann V, Gesierich B, Dichgans M. Acute infarcts cause focal thinning in remote cortex via degeneration of connecting fiber tracts. Neurology. 2015 Apr 21;84(16):1685-92.

2014

Duering M, Gesierich B, Seiler S, Pirpamer L, Gonik M, Hofer E, Jouvent E, Duchesnay E, Chabriat H, Ropele S, Schmidt R, Dichgans M. Strategic white matter tracts for processing speed deficits in age-related small vessel disease. Neurology. 2014 Jun 3;82(22):1946-50.

2013

Duering M, Csanadi E, Gesierich B, Jouvent E, Hervé D, Seiler S, Belaroussi B, Ropele S, Schmidt R, Chabriat H, Dichgans M. Incident lacunes preferentially localize to the edge of white matter hyperintensities: insights into the pathophysiology of cerebral small vessel disease. Brain. 2013 Sep;136(Pt 9):2717-26.

Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O'Brien JT, Barkhof F, Benavente OR, Black SE, Brayne C, Breteler M, Chabriat H, Decarli C, de Leeuw FE, Doubal F, Duering M, Fox NC, Greenberg S, Hachinski V, Kilimann I, Mok V, Oostenbrugge Rv, Pantoni L, Speck O, Stephan BC, Teipel S, Viswanathan A, Werring D, Chen C, Smith C, van Buchem M, Norrving B, Gorelick PB, Dichgans M; STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1). Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 2013 Aug;12(8):822-38.

2012

Duering M, Righart R, Csanadi E, Jouvent E, Hervé D, Chabriat H, Dichgans M. Incident subcortical infarcts induce focal thinning in connected cortical regions. Neurology. 2012 Nov 13;79(20):2025-8.

Duering M, Zieren N, Hervé D, Jouvent E, Reyes S, Peters N, Pachai C, Opherk C, Chabriat H, Dichgans M. Strategic role of frontal white matter tracts in vascular cognitive impairment: a voxel-based lesion-symptom mapping study in CADASIL. Brain. 2011 Aug;134(Pt 8):2366-75.

See all publications by Marco Düring

Human MRI scanner Siemens MAGNETOM Prisma

This scanner (taken into service in 2018) is dedicated to research use only and is fully equipped for state-of-the-art structural and functional neuroimaging.

Siemens MAGNETOM Prisma

Small animal PET-MRI Mediso nanoScan

This systems enables to conduct translational research projects in MR and PET imaging, such as the validation of imaging findings in transgenic models.

PET-MRI Mediso nanoScan

High-performance computation cluster

For data storage and post-processing, the group runs a specialized computation platform with workstations and a small computation cluster with custom software on-premises.

computation cluster

Marco Duering – Vascular Cognitive Impairment

Publications by Marco Düring

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