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  1. ISD Research
  2. Research Groups
  3. DichgansLab

Translational Stroke and Dementia Research – PI: Martin Dichgans

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We are interested in the molecular, cellular, and physiological mechanisms of stroke and cerebrovascular disease. We use genetic approaches to identify novel risk genes and explore their functional role in vitro and in vivo using genome-editing, proteomics, and imaging technology. We are particularly interested in cerebral small vessel disease and large artery atherosclerotic stroke.

A major starting point of our work are patients with stroke that are examined through prospective clinical studies along with healthy individuals. We apply genetic (GWAS and sequencing) and other omics techniques to identify novel targets and pathways relevant to specific mechanistically defined stroke subtypes. We use this information to explore relationships with informative intermediate (e.g. vascular, metabolic) and related phenotypes (e.g. coronary artery disease).

We have established genetic mouse models for cerebral small vessel disease (SVD) derived from the genetic discoveries (e.g. Notch3, HtrA1, Foxf2) and use these models to identify and characterize key molecular pathways (e.g. TGF-ß signaling) and cellular targets (e.g. brain pericytes) relevant to the pathogenesis of SVD.

Another area increasingly moving into the focus of our research is atherosclerosis. We in collaboration with others recently identified several risk loci for large artery stroke and are currently exploring the role of relevant genes (e.g. HDAC9, TSPAN2) in atherogenesis and vascular injury.

Contact: Martin Dichgans, MD,
Tel: +49-89-4400-46019
isd@med.uni-muenchen.de

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2018

Marco Duering, Sofia Finsterwalder, Ebru Baykara, Anil Man Tuladhar, Benno Gesierich, Marek J Konieczny, Rainer Malik, Nicolai Franzmeier, Michael Ewers, Eric Jouvent, Geert Jan Biessels, Reinhold Schmidt, Frank-Erik de Leeuw, Ofer Pasternak, Martin Dichgans ;Free water determines diffusion alterations and clinical status in cerebral small vessel disease Alzheimers Dement. 2018 Jun;14(6):764-774. doi: 10.1016/j.jalz.2017.12.007.

Rainer Malik, ( ... ), Dichgans M; Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet. 2018 Mar 12. doi: 10.1038/s41588-018-0058-3.

Andreas Zellner, Eva Scharrer, Thomas Arzberger, Chio Oka, Valérie Domenga-Denier, Anne Joutel, Stefan F Lichtenthaler, Stephan A Müller, Martin Dichgans, Christof Haffner;
CADASIL brain vessels show a HTRA1 loss-of-function profile. Acta Neuropathol. 2018 Jul;136(1):111-125. doi: 10.1007/s00401-018-1853-8.

Carolina Roselli, (...), Martin Dichgans, (...), Patrick T Ellinor; Multi-ethnic genome-wide association study for atrial fibrillation. Nat Genet. 2018 Sep;50(9):1225-1233. doi: 10.1038/s41588-018-0133-9.

Steffen Tiedt, Marco Duering, (...), Martin Dichgans; Serum neurofilament light: A biomarker of neuroaxonal injury after ischemic stroke. Neurology. 2018 Oct 2;91(14):e1338-e1347. doi: 10.1212/WNL.0000000000006282. 

Rainer Malik, ( ... ), Dichgans M; Genome-wide meta-analysis identifies 3 novel loci associated with stroke. Ann Neurol. 2018 Dec;84(6):934-939. doi: 10.1002/ana.25369.

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Dichgans, Martin, Prof. Dr. med. / PI

Asare, Yaw, Dr. rer. nat. / PostDoc

Beaufort, Nathalie, Dr. rer. nat. / PostDoc

Georgakis, Marios / PhD student

Gonzales Gallego Judit / postgraduate

Haffner, Christof, PD Dr. rer. nat. / PostDoc

Hellal, Farida, PhD / PostDoc

Kopczak, Anna, Dr. med. / clinician scientist

Lindner, Barbara / technical assistant

Malik, Rainer, Dr. rer. nat. / PostDoc

Prestel, Matthias, Dr. rer. nat. / PostDoc

Schneider, Melanie / technical assistant

Tiedt, Steffen, Dr. med. / clinician scientist

Völgyi, Katalin, Dr. rer. nat. / Post Doc

Waegemann, Karin, Dr. rer. nat. / Research coordinator

Yan, Guangyao / PhD student

Zellner, Andreas / PhD student

Ziesch, Natalie / technical assistant

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Martin Dichgans | CV

Personal Data


Martin Dichgans, MD

Date of birth: May 4th 1966

Place of birth: Basel (CH)

Professor, Ludwig-Maximilians University (LMU), Munich

Director, Institute for Stroke and Dementia Research

Chair, Stroke and Dementia Research


Scientific vita

since 2010 Founding Director, Institute for Stroke and Dementia Research, Klinikum der Universität München

Chair, Stroke and Dementia Research

Head, Interdisciplinary Stroke Center Munich, Klinikum der Universität München

since 2006 Professor of Neurology, Ludwig-Maximilians University (LMU), Munich

since 2001 Board Certificate in Neurology, Ludwig-Maximilians University (LMU), Munich

until 1993 Study of Medicine at the University of Heidelberg, Ludwig-Maximilians University (LMU), and Ann Arbor, Michigan (USA)


Coordinating Functions

since 2016 President, German Stroke Society (DSG) and Board of Directors (since 2014)

since 2015 Executive Committee, European Stroke Organization (ESO)

since 2014 Chair, Scientific Advisory Board, ERANET-NEURON, FP7 European Union

since 2012 Scientific Board and Research Coordinator, Munich Cluster of Systems Neurology (SyNergy)

since 2011 Coordinator, Clinical Research DZNE, Munich


Editor Roles and Editorial Boards

since 2017 Annals of Neurology, Editorial Board

since 2016 European Stroke Journal (ESO), Editorial Board

since 2015 Stroke (AHA), Section Editor

since 2013 Int J Stroke (WSO), Section Editor

since 2010 Frontiers in Stroke, Associate Editor

2011 – 2016 J Neurochemistry, Handling Editor

2010 – 2015 Stroke (AHA), Assistant Editor

2006 – 2010 Stroke (AHA), Section Editor


Fields of Interest

Stroke with a special focus on Genetics

Small Vessel Disease

Atherosclerosis


For information on Currently Funded Projects see ISD Research Support