Translational Stroke and Dementia Research – PI: Martin Dichgans
We are interested in the molecular, cellular, and physiological mechanisms of stroke and cerebrovascular disease. We use genetic approaches to identify novel risk genes and explore their functional role in vitro and in vivo using genome-editing, proteomics, and imaging technology. We are particularly interested in cerebral small vessel disease and large artery atherosclerotic stroke.
A major starting point of our work are patients with stroke that are examined through prospective clinical studies along with healthy individuals. We apply genetic (GWAS and sequencing) and other omics techniques to identify novel targets and pathways relevant to specific mechanistically defined stroke subtypes. We use this information to explore relationships with informative intermediate (e.g. vascular, metabolic) and related phenotypes (e.g. coronary artery disease).
We have established genetic mouse models for cerebral small vessel disease (SVD) derived from the genetic discoveries (e.g. Notch3, HtrA1, Foxf2) and use these models to identify and characterize key molecular pathways (e.g. TGF-ß signaling) and cellular targets (e.g. brain pericytes) relevant to the pathogenesis of SVD.
Another area increasingly moving into the focus of our research is atherosclerosis. We in collaboration with others recently identified several risk loci for large artery stroke and are currently exploring the role of relevant genes (e.g. HDAC9, TSPAN2) in atherogenesis and vascular injury.
Contact: Martin Dichgans, MD,
Georgakis MK, Gill D, Rannikmäe K, Traylor M, Anderson CD, Lee JM, Kamatani Y, Hopewell JC, Worrall BB, Bernhagen J, Sudlow CLM, Malik R, Dichgans M; Genetically Determined Levels of Circulating Cytokines and Risk of Stroke. Circulation. 2019 Jan 8;139(2):256-268. doi: 10.1161/CIRCULATIONAHA.118.035905.
Marco Duering, Sofia Finsterwalder, Ebru Baykara, Anil Man Tuladhar, Benno Gesierich, Marek J Konieczny, Rainer Malik, Nicolai Franzmeier, Michael Ewers, Eric Jouvent, Geert Jan Biessels, Reinhold Schmidt, Frank-Erik de Leeuw, Ofer Pasternak, Martin Dichgans ;Free water determines diffusion alterations and clinical status in cerebral small vessel disease Alzheimers Dement. 2018 Jun;14(6):764-774. doi: 10.1016/j.jalz.2017.12.007.
Rainer Malik, ( ... ), Dichgans M; Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet. 2018 Mar 12. doi: 10.1038/s41588-018-0058-3.
Andreas Zellner, Eva Scharrer, Thomas Arzberger, Chio Oka, Valérie Domenga-Denier, Anne Joutel, Stefan F Lichtenthaler, Stephan A Müller, Martin Dichgans, Christof Haffner;
CADASIL brain vessels show a HTRA1 loss-of-function profile. Acta Neuropathol. 2018 Jul;136(1):111-125. doi: 10.1007/s00401-018-1853-8.
Carolina Roselli, (...), Martin Dichgans, (...), Patrick T Ellinor; Multi-ethnic genome-wide association study for atrial fibrillation. Nat Genet. 2018 Sep;50(9):1225-1233. doi: 10.1038/s41588-018-0133-9.
Steffen Tiedt, Marco Duering, (...), Martin Dichgans; Serum neurofilament light: A biomarker of neuroaxonal injury after ischemic stroke. Neurology. 2018 Oct 2;91(14):e1338-e1347. doi: 10.1212/WNL.0000000000006282.
Loes Ca Rutten-Jacobs, Susanna C Larsson, Rainer Malik, Kristiina Rannikmäe, Cathie L Sudlow, Martin Dichgans, Hugh S Markus, Matthew Traylor; Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants. BMJ. 2018 Oct 24;363:k4168. doi: 10.1136/bmj.k4168.
Prof. Dr. med. Martin Dichgans
Read more about the PI on the next tab.
Dr. rer. nat. Yaw Asare / PostDoc
Dr. rer. nat. Nathalie Beaufort / PostDoc
Marios Georgakis / PhD student
Judit Gonzales Gallego / PhD student
Dr. rer. nat. Christof Haffner / PostDoc
Dr med. Anna Kopczak / clinician scientist
Barbara Lindner / technical assistant
Dr. rer. nat. Rainer Malik / PostDoc
Dr. rer. nat. Matthias Prestel / PostDoc
Melanie Schneider / technical assistant
I finished my education as a medical technical assistant in 2005 and immediately started working with Professor Martin Dichgans. I take care of organizational issues to all groups, place orders and do many histology works for my group members (e. g. preparing and cutting tissue, do staining’s, microscopy and sometimes evaluations). I am currently involved in projects aimed at identifying the mechanism underlying proatherogenic role of HDAC9 and exploring the therapeutic potential of HDAC9 inhibition for atheroprotection.
Dr. med. Steffen Tiedt / clinician scientist
I joined the group of Martin Dichgans at the ISD in 2013 after finishing my medical studies at the LMU in Munich and at Harvard. Beforehand, I received an MD for studying the regeneration of neurons after stroke (with Magdalena Götz, Institute of Physiology, LMU). Since being part of the ISD, my main research goal is to identify circulating biomarkers for diagnostic questions posed in the context of stroke and translate them into daily clinical application. For this purpose we established the CIRCULAting biomarkers after Stroke (CIRCULAS) study in 2014, which recruits patients with suspected stroke in the emergency department and has a strong focus on biosampling of these patients in the acute and subacute phase. We apply omics technologies (eg, RNA sequencing) and single-molecule assays to study different molecular classes such as microRNAs, proteins, and metabolites to advance our understanding of the pathophysiology of stroke and for their value as biomarkers.
Dr. rer. nat. Katalin Völgyi
Guangyao Yan / PhD student
Gabriele Wagenstetter / MD student
Andreas Zellner / PhD student
Yishu Huang / PhD student
Dr. rer. nat. Karin Waegemann / research coordinator
Martin Dichgans | CV
Martin Dichgans, MD
Date of birth: May 4th 1966
Place of birth: Basel (CH)
Professor, Ludwig-Maximilians University (LMU), Munich
Chair, Stroke and Dementia Research
since 2010 Founding Director, Institute for Stroke and Dementia Research, Klinikum der Universität München
Chair, Stroke and Dementia Research
Head, Interdisciplinary Stroke Center Munich, Klinikum der Universität München
since 2006 Professor of Neurology, Ludwig-Maximilians University (LMU), Munich
since 2001 Board Certificate in Neurology, Ludwig-Maximilians University (LMU), Munich
until 1993 Study of Medicine at the University of Heidelberg, Ludwig-Maximilians University (LMU), and Ann Arbor, Michigan (USA)
since 2016 President, German Stroke Society (DSG) and Board of Directors (since 2014)
since 2015 Executive Committee, European Stroke Organization (ESO)
since 2014 Chair, Scientific Advisory Board, ERANET-NEURON, FP7 European Union
since 2012 Scientific Board and Research Coordinator, Munich Cluster of Systems Neurology (SyNergy)
since 2011 Coordinator, Clinical Research DZNE, Munich
Editor Roles and Editorial Boards
since 2017 Annals of Neurology, Editorial Board
since 2016 European Stroke Journal (ESO), Editorial Board
since 2015 Stroke (AHA), Section Editor
since 2013 Int J Stroke (WSO), Section Editor
since 2010 Frontiers in Stroke, Associate Editor
2011 – 2016 J Neurochemistry, Handling Editor
2010 – 2015 Stroke (AHA), Assistant Editor
2006 – 2010 Stroke (AHA), Section Editor
Fields of Interest
Stroke with a special focus on Genetics
Small Vessel Disease