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                                      1. ISD Research
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                                      3. PlesnilaLab

                                      PlesnilaLab – Laboratory of Experimental Stroke Research

                                      • Research Focus
                                      • Publications
                                      • Team
                                      Visual Plesnila Group

                                      The main interest of the laboratory is to study the role of cerebral vessels for the pathophysiology of acute and chronic brain injury and to use the evolving knowledge for the development of novel therapeutic strategies for patients. For this purpose we use clinically relevant mouse models for acute and chronic brain injury and investigate neuro-vascular morphology and function by in vivo microscopy using conventional and 2-photon fluorescence microscopy.

                                      The work of the Laboratory of Experimental Stroke Research currently focuses around two topics: 1) the role of the cerebral microcirculation for brain injury after subarachnoid hemorrhage (SAH) and 2) the function of cerebral microvessels in physiological and pathological aging. Regarding SAH we discovered that early surgical decompression results in an increased rate of secondary bleedings thereby significantly worsening outcome and that inhaled nitric oxide reduces cerebral microvasospasms by -85% and blunts mortality. Further, we demonstrated that pial and intraparenchymal microvessels show a complete loss of CO2 reactivity after SAH. This finding suggests that SAH induces severe neuro-vascular dysfunction already within the first few hours after brain hemorrhage. Experiments on the aging brain demonstrated that already normal aging results in severe dysfunction of cerebral microvessels. While young vessels dilate and remain dilated upon repetitive neuronal activation, vessels from only eight month old mice dilate less and start to constrict with ongoing neuronal activity. These findings suggest that rather vascular and not necessarily neuronal dysfunction may be responsible for the reduced attention span at older age. Finally, we could demonstrate that the first pathological alteration in a mouse model of CADASIL is the retraction and death of microvascular pericytes. As a consequence the blood brain barrier becomes dysfunctional, plasma proteins enter the brain, and astrocytic end-feed detach from cerebral capillaries. These changes start to occur at an age of 4-8 month and precede white matter damage by more than one year. Accordingly, pericytes may represent the primary target for the cure of CADASIL.

                                      Figure (top): Mural cells expressing EGFP and DsRed under the PDGFRb and NG2 promoters line the cortical vasculature; labelling smooth muscle cells, fibroblasts and pericytes within the mouse cortex.

                                      Contact: Prof. Dr. med. Nikolaus Plesnila
                                      Tel: +49-89-4400-46219
                                      E-Mail: nikolaus.plesnila@med.uni-muenchen.de

                                      Sectretary: Hedwig Pietsch
                                      Tel: +49-89-4400-46220
                                      E-Mail: hedwig.pietsch@med.uni-muenchen.de

                                      experimental-research

                                      Publications by Nick Plesnila

                                      Key Publications 2018-2020

                                      > All Key Publications

                                      > All Publications

                                      2020

                                      Khalin I, Heimburger D, Melnychuk N, Collot M, Groschup B, Hellal F, Reisch A, Plesnila N, Klymchenko AS. Ultrabright Fluorescent Polymeric Nanoparticles with Stealth Pluronic Shell for Live Tracking in Mouse Brain. ACS Nano. 2020 Jul 17. Epub ahead of print. 

                                      2019

                                      Panahpour H, Terpolilli NA, Schaffert D, Culmsee C, Plesnila N. Central Application of Aliskiren, a Renin Inhibitor, Improves Outcome After Experimental Stroke Independent of Its Blood Pressure Lowering Effect. Front Neurol. 2019 Sep 4;10:942. 

                                      Anzabi M, Angleys H, Aamand R, Ardalan M, Mouridsen K, Rasmussen PM, Sørensen JCH, Plesnila N, Østergaard L, Iversen NK. Capillary flow disturbances after experimental subarachnoid hemorrhage: A contributor to delayed cerebral ischemia? Microcirculation. 2019 Apr;26(3):e12516. 

                                      2018

                                      Ganjam GK, Terpolilli NA, Diemert S, Eisenbach I, Hoffmann L, Reuther C, Herden C, Roth J, Plesnila N, Culmsee C. Cylindromatosis mediates neuronal cell death in vitro and in vivo. Cell Death Differ. 2018 Aug;25(8):1394-1407. 

                                      Frik J, Merl-Pham J, Plesnila N, Mattugini N, Kjell J, Kraska J, Gómez RM, Hauck SM, Sirko S, Götz M. Cross-talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury. EMBO Rep. 2018 May;19(5). 

                                      Liu H, Dienel A, Schöller K, Schwarzmaier SM, Nehrkorn K, Plesnila N, Terpolilli NA. Microvasospasms After Experimental Subarachnoid Hemorrhage Do Not Depend on Endothelin A Receptors. Stroke. 2018 Mar;49(3):693-699. 

                                      See all publications by Nikolaus Plesnila


                                      Plesnila, Nikolaus, Prof. Dr. med. / PI

                                      Biller, Janina / technical assistant

                                      Cara, Ardela / MD student

                                      Corvin, Christian / MD student

                                      Exner, Carina / MD 

                                      Filser, Severin, Dr. / Postdoc

                                      Groschup, Bernhard / PhD student

                                      Hu, Senbin / MD, PhD student

                                      Kamm, Katharina / Clinician Scientist (neu)

                                      Khalin, Igor. Dr. / Research fellow

                                      Lin, Xianjiang / MD, PhD student

                                      Lourbopoulos, Athanasios, Dr. / Clinician Scientist

                                      Mamrak, Uta / technical assistant

                                      Rauen, Katrin, Dr. / Clinician Scientist

                                      Şeker, Burcu, Dr. / Postdoc

                                      Schwarzmaier, Susanne, Dr / Clinician Scientist

                                      Schwarting, Julian / Clinician Scientist

                                      Shrouder, Joshua / PhD student

                                      Sienel, Rebecca / PhD student

                                      Terpolilli, Nicole, Dr. / Clinician Scientist

                                      Umeasalugo, Kosisochukwu / PhD student

                                      Valero Freitag, Susana / PhD student

                                      Wehn, Antonia / MD student

                                      Pietsch, Hedwig / Team Assistant


                                      Contact: Prof. Dr. med. Nikolaus Plesnila
                                      Tel: +49-89-4400-46219

                                      E-Mail: nikolaus.plesnila@med.uni-muenchen.de

                                      Sectretary: Hedwig Pietsch
                                      Tel: +49-89-4400-46220
                                      E-Mail: hedwig.pietsch@med.uni-muenchen.de

                                      Contact

                                      Institute for Stroke and Dementia Research (ISD)
                                      University Hospital, LMU Munich

                                      Director: Prof. Dr. med. Martin Dichgans

                                      Feodor-Lynen-Straße 17

                                      81377 Munich, Germany

                                      Phone: +49 (0)89 4400 46019
                                      www.isd-research.de
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                                      Neurologische Klinik und Poliklinik der Universität München

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                                      SyNergy – Munich Cluster for Systems Neurology

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