Higher sTREM2 and microglia PET associated with lower amyloid accumulation.

August 2020 | Alterations in the brain’s immune response are associated with higher risk of Alzheimer’s dementia, but the effect of microglia activation on amyloid-plaque deposition is elusive. ISD and DZNE investigators found higher CSF sTREM2 and TSPO PET, i.e. biomarkers of microglia activation, to be associated with lower amyloid accumulation in both mouse models of amyloid deposition and elderly individuals, suggesting a protective effect of TREM2-related microglia activity against a key Alzheimer’s pathology...

Events

September 3rd 2020 5pm on Zoom:

B.R.A.I.N. lecture (Zoom):

Perminder Sachdev, UNSW:
„The centenarian brain as a model of resilience“

Perminder Sachdev AM, MBBS, MD, PhD,Scientia Professor of Neuropsychiatry at UNSW Sydney (UNSW):

Research Groups

Translational Research – Martin Dichgans

Vascular Biology – Jürgen Bernhagen

Vascular Cognitive Impairment – Marco Düring

Brain Imaging and Biomarker – Michael Ewers

Neurobiology – Dominik Paquet

Stroke-Immunology – Arthur Liesz

Experimental Stroke Research – Nick Plesnila

Acute Brain Injury – Ali Ertürk

Molecular Biomarkers – Steffen Tiedt

Systems Neuroscience – Ozgun Gokce

Microbiome-Gut-Brain Interactions – Corinne Benakis