CRISPR-Cas9 has revolutionized disease-research, as it greatly simplifies targeted genome editing. However, CRISPR systems are not entirely accurate and can introduce potentially harmful additional mutations, called on-target effects. In a collaborative study with the DichgansLab, the PaquetLab identified widespread prevalence of on-target effects in clinically relevant CRISPR-edited iPS cells and describes broadly applicable tools to detect these unintended alterations. The new method improves the reliability of CRISPR editing...
Brain’s Resilience And Intelligence Networks (B.R.A.I.N. lecture)
Virtual keynote lectures on Cognitive Resilience/Reserve.
Speaker: Michael Belloy, Postdoctoral Research Fellow, Neurology and Neurological Science, Stanford University, CA, USA
Topic: "Klotho-VS heterozygosity reduces risk of Alzheimer’s disease in APOE4 carriers"