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Diffusion MRI alterations in the elderly are predominantly of vascular origin

$FIGURE 2 Simple regression analyses. Simple linear regression analyses between diffusion measures and Alzheimer’s disease (AD) biomarkers or small vessel disease (SVD) markers. Standardized beta is represented by color. ADNI, Alzheimer’s Disease Neuroimaging Initiative; β s , standardized beta; CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; CSF, cerebrospinal fluid; DELCODE, DZNE-Longitudinal Cognitive Impairment and Dementia Study; DIAN, Dominantly Inherited Alzheimer’s Network; FAu, uncorrected fractional anisotropy; FAt, free water corrected tissue compartment of fractional anisotropy; FW, free water content; MDu, uncorrected mean diffusivity; MDt, free water corrected tissue compartment of mean diffusivity; np, not possible (all patients had the maximum score); ns, not significant; PET, positron emission tomography; p-tau, phosphorylated- tau 181 ; SVCI, Seoul Vascular Cognitive Impairment study; SVD score, total SVD score; t-tau, total tau; UVCI, Utrecht Vascular Cognitive Impairment study; WMHvol, white matter hyperintensity volume$

August 2020 | Diffusion tensor imaging is widely used to study the brain microstructure, especially in memory clinic patients. The determinants of diffusion alterations are, however, largely unknown. A large-scale study led by ISD investigators addresses this important question by identifying cerebral small vessel disease as the main determinant of diffusion alterations...

Events

October 29th 2020 11am on Zoom:

SyNergy Seminar:
Friedhelm Serwane

Friedhelm Serwane

SyNergy ERC Academy / Department of Physics,
Ludwig-Maximilians-Universität München

„Towards neuronal disease modelling using retina organoids”

Research Groups

Translational Research – Martin Dichgans

Vascular Biology – Jürgen Bernhagen

Vascular Cognitive Impairment – Marco Düring

Brain Imaging and Biomarker – Michael Ewers

Neurobiology – Dominik Paquet

Stroke-Immunology – Arthur Liesz

Experimental Stroke Research – Nick Plesnila

Acute Brain Injury – Ali Ertürk

Molecular Biomarkers – Steffen Tiedt

Systems Neuroscience – Ozgun Gokce

Microbiome-Gut-Brain Interactions – Corinne Benakis

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Events overview

Research Groups Overview

Remote Events

September 22nd 2020, 17.00 pm
(CET, Berlin)

SyNergy Seminar: Christoph Scheiermann
University of Geneva & Ludwig Maximilian University of Munich
„Circadian and neural mechanisms governing adaptive immune responses“

October 29th 2020, 11.00 am
(CET, Berlin)

SyNergy Seminar: Friedhelm Serwane,
SyNergy ERC Academy / Department of Physics, LMU
„Towards neuronal disease modelling using retina organoids”

People in front of ISD Building © Stefan-Müller-Naumann

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