News

May 2020

Taming widespread collateral damage of CRISPR editing

CRISPR-Cas9 has revolutionized disease-research, as it greatly simplifies targeted genome editing. However, CRISPR systems are not entirely accurate and can introduce potentially harmful additional mutations, called on-target effects. In a collaborative study with the DichgansLab, the PaquetLab identified widespread prevalence of on-target effects in clinically relevant CRISPR-edited iPS cells and describes broadly applicable tools to detect these unintended alterations. The new method improves the reliability of CRISPR editing...

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Research Groups

DichgansLab – Translational Research

BernhagenLab – Vascular Biology

DueringLab – Vascular Cognitive Impairment

EwersLab – Brain Imaging and Biomarker

PlesnilaLab – Experimental Stroke Research

LieszLab – Stroke-Immunology

ErturkLab – Acute Brain Injury

PaquetLab – Neurobiology

BenakisLab – Microbiome–Gut–Brain Interactions

GokceLab – Systems Neuroscience

Brain’s Resilience And Intelligence Networks (B.R.A.I.N. lecture)
Virtual keynote lectures on Cognitive Resilience/Reserve.

Speaker: Michael Belloy, Postdoctoral Research Fellow, Neurology and Neurological Science, Stanford University, CA, USA

Topic: "Klotho-VS heterozygosity reduces risk of Alzheimer’s disease in APOE4 carriers"

Time: May 28th 2020, 5 pm (CET, Berlin) 

Schedule & Zoom link >