Unsere Webseite nutzt Cookies, damit die User-Experience gesteigert wird. Bitte beachten Sie, dass ohne Cookies einige Funktionalitäten nicht mehr ausführbar sind (z.B. Formulare). Ausführlichere Hinweise zu Cookies
OK
LMU Munich University Hospital
  • Research Groups
      Dichgans Lab
        Bernhagen Lab
          Liesz Lab
            Ewers Lab
              Paquet Lab
                Plesnila Lab
                  Erturk Lab
                    Duering Lab
                      Benakis Lab
                        Franzmeier Lab
                          Gokce Lab
                            Jäkel Lab
                              Tiedt Lab
                            • News
                            • Publications
                            • Support
                            • About us
                                Contact
                                  How to get there
                                    Management
                                      Scientific Advisory Board
                                        Imprint
                                          Privacy Policy
                                            Media
                                              Diversity at the ISD
                                            • Jobs
                                            • For Patients
                                            1. ISD Research
                                            2. News

                                            News


                                            Complicated Carotid Artery Plaques and Risk of Recurrent Ischemic Stroke or TIA

                                            Complicated Carotid Artery Plaques and Risk of Recurrent Ischemic Stroke or TIA

                                            May 2022 – Complicated nonstenosing carotid artery plaques (CAPs) are an under-recognized cause of stroke. Applying high-resolution contrast-enhanced carotid MRI to patients with acute ischemic stroke, ISD investigators found complicated CAP ipsilateral to acute ischemic anterior circulation stroke to be associated with an increased risk of recurrent ischemic stroke or TIA. Carotid plaque imaging identifies high-risk patients who might be suited for inclusion into future secondary prevention trials >>

                                            Brain connectivity is associated with tau deposition in 4-repeat tauopathies

                                            March 2022 – Tau pathology drives neuronal dysfunction in 4-repeat tauopathies. Here, ISD researchers combined tau-PET, resting-state fMRI and histopathology data, to show that brain connectivity is associated with tau deposition patterns in patients with 4-repeat tauopathies >>

                                            EMBO Workshop - Stroke-Immunology

                                            February 2022 – The EMBO Workshop on Stroke-Immunology running 9 – 12 March in Munich, Germany, will provide a platform for uniting experts in the field with leading scientists from related research areas, including immunology, neuroscience, and advanced research tools. This shall facilitate close interactions and lasting relationships between established scientists in this emerging research area with leaders in related fields, accelerating further developments in stroke-immunology >>

                                            Leducq grant on circadian mechanisms in stroke

                                            November 2021 – The Leducq Foundation - a charitable organization that funds collaborative research in cardiovascular disease and stroke – awarded a new trans-atlantic network of excellence on circadian effects in stroke (coordinators: Eng Lo, Boston, & Alastair Buchan, Oxford). Together with basic, translational, and clinical scientists in the USA, UK, and Spain, the ISD (PI: S. Tiedt) now seeks to understand how circadian biology affects stroke pathophysiology with the ultimate aim to identify novel therapeutic targets for stroke >>

                                            m4 Award 2021 © BioM / Claude Alberth

                                            m4 Award for Bernhagen Lab

                                            October 2021 – The Bernhagen (ISD) and Kapurniotu (TUM) labs are among the awardees of this year’s m4 competition for innovative biomedical projects by the Bavarian State Ministry of Economic Affairs. Despite significant progress, atherosclerotic disease (stroke and myocardial infarction) remains the leading cause of death. Tackling residual inflammatory risk has evolved as a promising preventive strategy. The m4 award will enable the team to develop chemokine receptor mimics as drug leads to selectively inhibit key atherosclerosis-causing chemokine >>

                                            Role of HTRA1 in brain white matter hyperintensities

                                            October 2021 – In a whole-exome sequencing study on >16.000 individuals, ISD investigators found rare variants in the protease domain of HTRA1 to associate with brain WMH burden. The frequency of such variants in the general population was 1:450 and their presence corresponded to a larger effect than meeting the criteria for conventional vascular risk factors. Variants in EGFL8, which falls into a common pathway with HTRA1, also associated with WMH burden >>

                                            Interneurons trigger cortical spreading depolarizations (CSDs)

                                            September 2021 – CSDs are the electrophysiological correlate of migraine aura and involved in the propagation of brain damage after ischemic and traumatic brain injury. Using a novel migraine mouse model, the Plesnila Lab in collaboration with Tobias Freilinger, Holger Lerche (Tübingen, Germany), and Massimo Mantegazza (Nice, France) found that CSDs are triggered by inhibitory interneurons. This counterintuitive finding unravels the so far unknown cellular mechanism for the initiation of CSDs >>

                                            Role of complement component C4 in age-related white matter injury

                                            July 2021 – Age-related loss of white matter integrity is a major determinant of cognitive decline and dementia. Analysing data from >30.000 UK Biobank participants, ISD investigators in collaboration with Matthew Traylor (London) found the complement component C4-BS variant to associate with age-related WM injury. These findings suggest a role of the complement systems and of gene-environment interactions in age-related loss of white matter microstructural integrity...

                                            de Leon Senior Scientist Prize for Michael Ewers

                                            July 2021 – Michael Ewers received the prestigious 2021 de Leon Prize for Neuroimaging awarded at the Alzheimer Association International Conference in Denver. The de Leon Prize in Neuroimaging recognizes senior scientists and is shared with Dr. Juan Fortea, Spain...

                                            Neitzel-et-al.jpg

                                            Common KLOTHO SNP protects against Tau pathology

                                            June 2021 – ISD researchers found that a common variant in the anti-aging gene KLOTHO is associated with reduced fibrillar tau, a key pathology in Alzheimer’s disease...

                                            Life’s simple 7 and incident dementia risk

                                            March 2021 – Leveraging data from the UK Biobank (N=229,976 participants) ISD investigators examined whether cardiovascular health measured by the ‘Life’s simple 7’ score is associated with incident all-cause dementia. They found that higher blood pressure was associated with higher risk of dementia both in longitudinal and Mendelian Randomization analyses. These findings underscore the importance of blood pressure control in midlife to mitigate dementia risk...

                                            Genetic downregulation of IL-6 signaling leads to a favourable cardiometabolic profile

                                            March 2021 – Drugs targeting IL6 signaling have been approved for autoimmune diseases but the repurposing potential for other indications remains unknown. ISD researchers developed a genetic score predicting IL6 signaling activity over lifetime. In a phenome-wide association study they found genetically downregulated IL6 signaling to be associated with a favourable cardiometabolic profile including a lower risk of coronary artery disease and diabetes, and an increase in HDL cholesterol levels. Their results support repurposing of IL6R blockade as a strategy for lowering vascular risk.​..

                                            AIM2-inflammasome signaling cascade causes post-stroke immunosuppression and secondary infections

                                            March 2021 – Stroke patients are predisposed to life-threatening infections after the initial ischemic event. This phenomenon is caused by a severe state of post-injury immunosuppression, which is characterized by a loss of T cells. Stefan Roth (Liesz Lab) in collaboration with others demonstrates that monocytes sense injury-released cell-free DNA via the AIM2 inflammasome inducing extrinsic T cell death. Uncovering this mechanism could open up new therapeutical approaches...

                                            Sarah Jäkel

                                            Sarah Jäkel joins ISD as a Junior Group Leader 

                                            March 2021 – As an Emmy Noether awardee, Sarah Jäkel explores the role of oligodendrocytes – the myelin forming cells in the central nervous system – in the pathogenesis of Alzheimer’s disease. Applying cutting-edge transcriptomic approaches such as single-nuclei RNA-sequencing to postmortem human brain tissue as well as two and three-dimensional human stem cell-derived oligodendrocyte cultures as model systems, she aims to characterize the functional oligodendrocyte cell states that she recently described and unravel their individual contribution to disease.​..

                                            Stroke Immunology Conference

                                            First International Stroke-Immunology Conference | Online

                                            March 2021 – Co-organized by Arthur Liesz (ISD) and Adam Denes (Budapest) the 1st Stroke-Immunology Conference was hosted fully virtual. The meeting was attended by 470 participants from 23 countries with contributions from 34 live speakers and 32 pre-recorded webcasts. The aim of this conference was to convene scientists working on inflammatory mechanisms in acute brain ischemia with leading experts on related research topics in neuroimmunology, neuroscience and neuroimaging. The meeting will be continued in 2022 and is scheduled for March 9-11th in a hybrid format.

                                            white matter associated microglia

                                            White matter aging drives microglial diversity 

                                            February 2021 – Aging and vascular risk factors are associated with white matter (WM) lesions and loss, but the role of microglia in the aging WM has been elusive. Using single-cell RNA sequencing, ISD and DZNE investigators identified WM-associated microglia (WAMs), which form in a TREM2-dependent but APOE independent manner and are characterized by age-dependent activation of genes implicated in phagocytic activity and lipid metabolism. Thus, WAMs may represent a potentially protective response required to clear degenerated myelin accumulating during WM aging and disease...

                                            News Archive

                                            Follow us on Twitter: @ISD_Research

                                            Contact

                                            Institute for Stroke and Dementia Research (ISD)
                                            University Hospital, LMU Munich

                                            Director: Prof. Dr. med. Martin Dichgans

                                            Feodor-Lynen-Straße 17
                                            81377 Munich, Germany

                                            Phone: +49 (0)89 4400 46019
                                            www.isd-research.de
                                            Send a Mail

                                            Partners

                                            Neurologische Klinik und Poliklinik der Universität München

                                            DZNE – Deutsches Zentrum für Neurodegenerative Erkrankungen

                                            SyNergy – Munich Cluster for Systems Neurology

                                            Redakteurs Log-In
                                            • Imprint
                                            • Privacy Policy
                                            © Institute for Stroke and Dementia Research (ISD)
                                          • LMU Munich
                                          • University Hospital
                                          • ISD Research

                                            • Research Groups
                                              • Dichgans Lab
                                              • Bernhagen Lab
                                              • Liesz Lab
                                              • Ewers Lab
                                              • Paquet Lab
                                              • Plesnila Lab
                                              • Erturk Lab
                                              • Duering Lab
                                              • Benakis Lab
                                              • Franzmeier Lab
                                              • Gokce Lab
                                              • Jäkel Lab
                                              • Tiedt Lab
                                            • News
                                            • Publications
                                            • Support
                                            • About us
                                              • Contact
                                              • How to get there
                                              • Management
                                              • Scientific Advisory Board
                                              • Imprint
                                              • Privacy Policy
                                              • Media
                                              • Diversity at the ISD
                                            • Jobs
                                            • For Patients