News
Complicated Carotid Artery Plaques and Risk of Recurrent Ischemic Stroke or TIA
Brain connectivity is associated with tau deposition in 4-repeat tauopathies
Leducq grant on circadian mechanisms in stroke
Role of HTRA1 in brain white matter hyperintensities
Interneurons trigger cortical spreading depolarizations (CSDs)
Role of complement component C4 in age-related white matter injury
de Leon Senior Scientist Prize for Michael Ewers
Common KLOTHO SNP protects against Tau pathology
Life’s simple 7 and incident dementia risk
Genetic downregulation of IL-6 signaling leads to a favourable cardiometabolic profile
March 2021 – Drugs targeting IL6 signaling have been approved for autoimmune diseases but the repurposing potential for other indications remains unknown. ISD researchers developed a genetic score predicting IL6 signaling activity over lifetime. In a phenome-wide association study they found genetically downregulated IL6 signaling to be associated with a favourable cardiometabolic profile including a lower risk of coronary artery disease and diabetes, and an increase in HDL cholesterol levels. Their results support repurposing of IL6R blockade as a strategy for lowering vascular risk...
AIM2-inflammasome signaling cascade causes post-stroke immunosuppression and secondary infections
First International Stroke-Immunology Conference | Online
White matter aging drives microglial diversity