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                                          1. ISD Research
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                                          News


                                          An AIM2-inflammasome signaling cascade causes post-stroke immunosuppression and secondary infections.

                                          March 2021 – Stroke patients are predisposed to life-threatening infections after the initial ischemic event. This phenomenon is caused by a severe state of post-injury immunosuppression, which is characterized by a loss of T cells. In a collaboration with investigators from Germany and China, Stefan Roth (Liesz Lab) demonstrates that monocytes sense injury-released cell-free DNA via the AIM2 inflammasome inducing extrinsic T cell death. Uncovering this mechanism could open up new therapeutical approaches...

                                          Stroke Immunology Conference

                                          First International Stroke-Immunology Conference | Online

                                          March 2021 – The Stroke-Immunology Conference 2021 is an inaugural meeting co-organized by Arthur Liesz (ISD) and Adam Denes (Budapest). Due to the COVID pandemic this conference was hosted fully virtual and took place from March 1st-3rd 2021. The meeting was attended by 470 participants from 23 countries with contributions from 34 live speakers and 32 pre-recorded webcasts. The aim of this conference was to convene scientists working on inflammatory mechanisms in acute brain ischemia with leading experts on related research topics in neuroimmunology, neuroscience and neuroimaging. The meeting will be continued next year (Stroke-Immunology Conference 2022) and is scheduled for March 9-11th in a hybrid format.

                                          white matter associated microglia

                                          White matter aging drives microglial diversity 

                                          February 2021 – Aging and vascular risk factors are associated with white matter (WM) lesions and loss, but the role of microglia in the aging WM has been elusive. Using single-cell RNA sequencing, ISD and DZNE investigators identified WM-associated microglia (WAMs), which form in a TREM2-dependent but APOE independent manner and are characterized by age-dependent activation of genes implicated in phagocytic activity and lipid metabolism. Thus, WAMs may represent a potentially protective response required to clear degenerated myelin accumulating during WM aging and disease...

                                          Bayer Early Excellence in Science Award for Nicolai Franzmeier 

                                          December 2020 – Nicolai Franzmeier is being recognized with the 2020 Bayer Early Excellence in Science Award in Medical Sciences, which is awarded by the Bayer foundation to excellent young scientists and physicians in the early stages of their academic and clinical research careers. He received the award for developing novel neuroimaging tools to investigate Alzheimer’s disease progression, showing that tau pathology, i.e. the key driver of cognitive decline, spreads across brain networks...

                                          Patient-centered prediction of tau spreading in Alzheimer’s

                                          November 2020 | The spreading of tau pathology throughout the brain is the major driver of cognitive decline in Alzheimer’s disease. ISD researchers developed a new functional connectivity-based prediction model for the forecasting of future tau PET spreading patterns in Alzheimer’s disease patients. This patient-centered prediction model provides a precision-medicine tool for predicting disease progression and defining a patient-tailored outcome measure to boost power in clinical trials targeting tau pathology...

                                          Designed chemokine receptor mimic blocks atherosclerosis by chemokine-specific targeting

                                          November 2020 | Atherosclerosis is the main cause of stroke and myocardial infarction. While the inflammatory paradigm is established, the development of anti-cytokine/chemokine therapeutics for atherosclerosis has remained challenging. A team of investigators led by the Bernhagen (ISD) and Kapurniotu (TUM) labs designed peptide-based mimics of the chemokine receptor CXCR4 that block experimental atherosclerosis. The new compounds selectively target pro-atherogenic chemokine pathways, whereas homeostatic pathways are spared. The study is published in Nat Communications...


                                          Central Figure Capias

                                          Complicated Carotid Artery Plaques as a Cause of Cryptogenic Stroke

                                          November 2020 | In up to 30% of patients the aetiology of stroke remains unknown. Applying high-resolution contrast-enhanced carotid MRI to patients with acute ischemic stroke ISD investigators identified nonstenosing complicated carotid artery plaques (cCAP) as an underrecognized cause of stroke. The most frequent feature of ipsilateral cCAP was intraplaque haemorrhage (89%), which can be reliably detected by conventional MRI sequences. Whether integrating carotid MRI into the diagnostic workflow would add clinical decision-making remains to be explored...


                                          SARS-CoV-2-entry-into-cells

                                          Neuropilin-1 opens the door to SARS-CoV-2 cell entry and infectivity

                                          November 2020 | An international research team, coordinated by Mikael Simons (DZNE) with participation of the Gokce Lab identified neuropilin-1 as a factor that facilitates SARS-CoV-2 entry into cells including of the central nervous system. The study is now published in “Science”.


                                          FIGURE 2 Simple regression analyses. Simple linear regression analyses between diffusion measures and Alzheimer’s disease (AD) biomarkers or small vessel disease (SVD) markers. Standardized beta is represented by color. ADNI, Alzheimer’s Disease Neuroimaging Initiative; β s , standardized beta; CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; CSF, cerebrospinal fluid; DELCODE, DZNE-Longitudinal Cognitive Impairment and Dementia Study; DIAN, Dominantly Inherited Alzheimer’s Network; FAu, uncorrected fractional anisotropy; FAt, free water corrected tissue compartment of fractional anisotropy; FW, free water content; MDu, uncorrected mean diffusivity; MDt, free water corrected tissue compartment of mean diffusivity; np, not possible (all patients had the maximum score); ns, not significant; PET, positron emission tomography; p-tau, phosphorylated- tau 181 ; SVCI, Seoul Vascular Cognitive Impairment study; SVD score, total SVD score; t-tau, total tau; UVCI, Utrecht Vascular Cognitive Impairment study; WMHvol, white matter hyperintensity volume

                                          Diffusion MRI alterations in the elderly are predominantly of vascular origin

                                          August 2020 | Diffusion tensor imaging is widely used to study the brain microstructure, especially in memory clinic patients. The determinants of diffusion alterations are, however, largely unknown. A large-scale study led by ISD investigators addresses this important question by identifying cerebral small vessel disease as the main determinant of diffusion alterations... 


                                          Zuckerberg-Initiative

                                          Chan Zuckerberg Initiative (CZI) Award for Ozgun Gokce

                                          August 2020 | Ozgun Gokce group leader at the ISD received the CZI Neurodegeneration Challenge Network (NDCN) Collaborative Pairs Pilot Projects award together with Michael Simons (DZNE-Munich). This new grant represents the next phase of the CZI Neurodegeneration Challenge Network (NDCN) an interdisciplinary collaborative network launched in December 2018. The funding is aimed to support initial pilots for innovative exploratory ideas. Successful projects and teams will receive further funding in the 2nd phase pending scientific review...


                                          CSF sTREM2

                                          Higher sTREM2 and microglia PET associated with lower amyloid accumulation.

                                          August 2020 | Alterations in the brain’s immune response are associated with higher risk of Alzheimer’s dementia, but the effect of microglia activation on amyloid-plaque deposition is elusive. ISD and DZNE investigators found higher CSF sTREM2 and TSPO PET, i.e. biomarkers of microglia activation, to be associated with lower amyloid accumulation in both mouse models of amyloid deposition and elderly individuals, suggesting a protective effect of TREM2-related microglia activity against a key Alzheimer’s pathology...


                                          Steffen Tiedt

                                          Junior Research Group Award for Steffen Tiedt

                                          August 2020 | Steffen Tiedt, a clinician-scientist at the ISD, was awarded 1.0M € by the Corona-Foundation for a research program on “Precision Medicine in Stroke (PROMISE)”. The support will enable him to establish a Junior Research Group that will focus on identifying circulating molecular signatures by profiling samples both from stroke patients and mouse models. Such signatures could aid stroke diagnostics and enhance our understanding of stroke pathophysiology...


                                          Circulating Metabolites

                                          Metabolic signature differentiates ischemic stroke from stroke mimics

                                          August 2020 | Early discrimination of patients with ischemic stroke (IS) from stroke mimics (SM) is important to allocate treatments, but poses a diagnostic challenge. Applying untargeted metabolomics to serum samples from > 800 patients with stroke-like symptoms, ISD investigators identified a signature of circulating metabolites that differentiates IS from SM with higher accuracy than multimodal cranial computed tomography upon hospital admission...


                                          Real-time Single Nanoparticle Tracking

                                          Visualization of biocompatible nanoparticles

                                          July 2020 | Biocompatible nanoparticles have huge therapeutic potential, but could so far not be visualized. In a collaboration with investigators from Strasbourg, Igor Khalin (Plesnila Lab) now demonstrates that specifically designed ultra-bright nanoparticles can be traced in vivo by 2-photon microscopy. This technological breakthrough greatly improves our understanding how to target therapeutic compounds to the CNS...


                                          Ali Erturk

                                          Rolf-Becker Prize 2020 awarded to ISD scientist

                                          July 2020 | Ali Erturk was awarded with the "Rolf-Becker"-Prize for one of the best scientific outputs in 2019/2020 by the Medical Faculty of LMU Munich. He received this prestigious award for his work on Deep Learning revealing therapeutic antibody targeting in the entire body published in CELL...


                                          HDAC9

                                          HDAC9 – from GWAS discovery to mechanisms and therapeutic targeting

                                          June 2020 | Drug targets with support from human genetics have a higher probability of reaching phase III clinical trials and regulatory approval. Following their GWAS-based discovery of HDAC9 as a major risk locus for human atherosclerosis, ISD investigators identified a detailed mechanism linking HDAC9 to vascular inflammation. They further demonstrate that therapeutic inhibition of this HDAC9-dependent pathway confers plaque stability on top of atheroprotection …  


                                          Martin Dichgans, ISD as President of ESOC

                                          Martin Dichgans to serve ESO as its President

                                          June 2020 The European Stroke Organisation (ESO) has rapidly grown to become a driving force in convening stroke researchers around the globe, promoting research and educational events and optimising stroke care in Europe and beyond. Starting in May 2020 Martin Dichgans currently serves ESO as its new President. His focus will be on promoting the development of the ESO Guidelines and further strengthening ESOs role within the community


                                          Cell Reports Figure

                                          Taming widespread collateral damage of CRISPR editing

                                          May 2020 CRISPR-Cas9 has revolutionized disease-research, as it greatly simplifies targeted genome editing. However, CRISPR systems are not entirely accurate and can introduce potentially harmful additional mutations, called on-target effects. In a collaborative study with the DichgansLab, the PaquetLab identified widespread prevalence of on-target effects in clinically relevant CRISPR-edited iPS cells and describes broadly applicable tools to detect these unintended alterations. The new method improves the reliability of CRISPR editing...


                                          mousebrain

                                          Machine learning analysis of whole mouse brain vasculature 

                                          March 2020 The Ertürk lab in collaboration with others (ISD, Helmholtz Munich and TUM) developed an artifical intelligence aided tool to study the vasculature in complete transparent mouse brains. Using 3D microscopy, they visualized the underlying complex network of all brain vessels at the capillary level. Their new tool can generate reference maps of the adult mouse brain vasculature, which could be used to model synthetic cerebrovascular networks. On this basis, unknown vascular properties can be discovered and biological models can be confirmed...


                                          AD figure 

                                          Aβ deposition associated with white matter alterations in cognitive normal people 

                                          March 2020 In an international collaboration, ISD researchers report increased amyloid PET uptake to be associated with higher age-related fiber tract alterations and white matter hyperintensities in cognitively asymptomatic people...


                                          Transparent Organs

                                          Transparent human organs – 3D maps at cellular level

                                          February 2020 The Ertürk lab (ISD and Helmholtz Munich) managed to make intact human organs transparent. Using microscopic imaging they visualized underlying complex structures of see-through organs at the cellular level. Resulting organ maps could serve as templates for 3D-bioprinting technologies. This eventually could contribute to the creation of on demand artificial organs for patients in need...


                                          Alzheimer’s & Dementia 

                                          Digital medicine model of cognitive worsening in Alzheimer’s disease

                                          February 2020 In a large collaborative study with the North American DIAN and ADNI studies, ISD researchers developed a fully automated and cross-validated machine-learning algorithm for the prediction of disease progression in Alzheimer’s disease. The biofluid and neuroimaging derived model allows to predict the rate of cognitive decline over a clinically relevant time window of 4 years….


                                          Role of HDL-C in cerebral Small Vessel Disease

                                          January 2020 Using Mendelian Randomization ISD investigators showed that genetic predisposition to higher HDL-C, specifically to cholesterol in medium-sized HDL, is associated with small vessel stroke and white matter injury. Their analyses indicate that HDL-C-raising strategies could be considered for the prevention of ischemic small vessel disease but the net benefit of such an approach needs to be tested in a randomized controlled trial...


                                          Tau Spreadings

                                          Tau spreading associated with functional connectivity in Alzheimer’s disease

                                          January 2020 A multinational study led by the Ewers Lab and first author Nicolai Franzmeier shows that functional brain architecture predicts the spatial patterns of the gradual spreading of tau pathology in Alzheimer's disease, supporting in-vitro findings of trans-neuronal tau propagation...  


                                          Nature Communications

                                          Improved Genomic Risk Score (GRS) for Stroke

                                          December 2019 ISD researchers developed a metaGRS for ischaemic stroke (IS) that outperforms previous GRS and identifies a subset of individuals at monogenic levels of risk. Individuals in the top 0.25% of the metaGRS have a threefold increased risk of IS. The results suggest that, for individuals with a high metaGRS, achieving risk factor levels recommended by current guidelines may be insufficient to mitigate risk...


                                          Cell Cover

                                          Deep Learning Reveals Therapeutic Antibody Targeting in the Entire Body

                                          December 2019 Combining clearing technology with deep learning algorithms ISD investigators developed an integrated pipeline for automated quantification of cancer metastases and therapeutic antibody targeting (DeepMACT) that enables analysing the size, shape, and spatial distribution of metastases, and the degree to which metastases are targeted by therapeutic monoclonal antibodies in entire mice...


                                          ERC Starting Grant for Arthur Liesz

                                          ERC Consolidator Grant for Ali Ertürk

                                          December 2019 Ali Ertürk received a prestigious ERC Consolidator Grant for his research project CALVARIA ‘Translational Aspects of the Discovery of Skull-Meninges Connections’. SMCs where recently discovered by Ali Ertürk and others and enable immune cells to migrate into the brain suggesting they could play a role in brain disorders including stroke and dementia ...


                                          Hertie Network of Excellence in Clinical Neuroscience

                                          Hertie Network of Excellence in Clinical Neuroscience

                                          November 2019 Neuroscientists at LMU and TUM have been awarded members of the Hertie Network of Excellence in Clinical Neuroscience. The program provides support of junior scientists and facilitates collaborations across participating sites. The scientific focus of the Munich site (Speakers: M. Dichgans and Thomas Korn) is on neurovascular, neurodegenerative, and neuroinflammatory diseases and underlying mechanisms...


                                          strokemicrobiomics

                                          Medical Excellence fellowship for ISD Researcher

                                          November 2019 Philip Melton, MD student in the Liesz lab, was awarded the „Medical Excellence“ Fellowship 2019 in the field of Neuroscience for „StrokeMicroBiomics“. The project explores long-term microbiome dysbiosis and metabolomic changes in stroke patients...


                                          georgakis-publication

                                          Circulating MCP-1 levels associate with stroke risk

                                          September 2019 Expanding on their previous Mendelian Randomisation study (CIRCULATION 2019) ISD researchers now provide further evidence for a causal role of MCP-1 in stroke. In a meta-analysis of observational data from 17,180 stroke-free individuals they found higher circulating MCP-1 levels to be associated with long-term risk of incident ischemic stroke...


                                          Protective effects of TREM2 in Alzheimer's Disease

                                          August 2019 The teams of M. Ewers and C. Haass found higher cerebrospinal fluid comcentrations of TREM2, a biomarker of microglia activation, to slow down cognitive decline in Alzheimer's Disaease...


                                          The contribution of acute infarcts to cerebral small vessel disease progression

                                          Novel insights into small vessel disease progression

                                          July 2019 Using a prospective, high-frequency serial imaging study, a team of researchers at ISD and Radboudumc Nijmegen identified acute infarcts as the cause of incident lacunes and almost a third of incident microbleeds. In contrast, the progression of white matter hyperintensities was independent from acute infarcts. These new insights were enabled through a unique study design with monthly MRI exams...


                                          Retreat 2019 Photo by Antonia Weingart
                                          ☀︎

                                          ISD Research Retreat

                                          July 2019 July 10th and 11th ISD research teams met for the yearly scientific retreat to present their projects and discuss the science. At the heart of this meeting were presentations from all Ph.D. students, including an evning poster session. The last year brought about important achievements both scientifically and with regard to expertise and infrastructure. The meeting further served as an opportunity to familiarize people with the medium- and long-term strategy of ISD...


                                          NCL Grant 

                                          Research support from NCL Foundation for PaquetLab

                                          July 2019 The project led by Christian Grimm (Walther‐Straub‐Institute) and Dominik Paquet (ISD) is supported with 86.000 Euros by the German Neuronal Ceroid Lipofuscinosis Foundation (NCL) and aims to develop novel treatment strategies for childhood dementia...


                                          Brain Imaging Nature Article

                                          BIN1 SNP associated with tau deposition in Alzheimer’s

                                          April 2019 A multinational study led by Michael Ewers and his team suggests that enhanced tau pathology may underlie the increased risk of Alzheimer’s conferred by the BIN1 single nucleotide polymorphism - the second most important genetic risk factor of AD...


                                          BDNF-Val66Met SNP

                                          BDNF-Val66Met SNP modulates hippocampus disconnection in Alzheimer’s

                                          April 2019 ISD researchers found a common variant in the BDNF gene to modulate the impact of amyloid pathology on hippocampal network connectivity and memory in Alzheimer’s disease...


                                          BRAIN price Lundbeck

                                          BRAIN price for French CADASIL researchers

                                          March 2019

                                          Congratulations to our longstanding collaborators Marie-Germain Bousser, Anne Joutel, Hugues Chabriat, & Elisabeth Tournier-Lasserve (Paris, Fr.) for receiving the prestigious BRAIN price. Their groundbreaking work on CADASIL has profoundly influenced the understanding of cerebral small vessel disease & vascular cognitive impairment...


                                          tau pathology

                                          Functional connectivity associated with tau pathology

                                          February 2019

                                          A combined fMRI and tau PET study in Alzheimer’s disease by Michael Ewers and team shows that the spatial pattern of tau pathology is predicted by functional network connectivity, suggesting that cross-talk between brain regions is conducive to tau spreading...


                                          Skull-meninges connections revealed by vDISCO

                                          Skull-meninges connections revealed by vDISCO

                                          January 2019

                                          The Erturk group developed a nanobody-based immunolabeling method, vDISCO, that enables imaging subcellular details in transparent mice. They uncovered neuronal projections and skull–meninges connections in whole adult mice that are likely to have relevance in both health and disease...


                                          brain lymphatics

                                          NIH R01 Grant on brain lymphatics

                                          November 2018

                                          Ali Ertürk has been awarded $715.000 from NIH (USA) to explore the role of brain lymphatic/glymphatic systems in dementia and ageing in collaboration with Maiken Nedergaard (Rochester University, New York)...


                                          Novel risk loci for stroke

                                          Novel risk loci for stroke

                                          November 2018

                                          A genome-wide meta-analysis involving almost 900.00 subjects from the MEGASTROKE consortium and UK Biobank identified new risk loci for stroke among them endothelial nitric oxide synthase (NOS3). The study further suggests that genetic variation in the NOS - nitric oxide (NO) pathway in part affects stroke risk via variation in blood pressure...


                                          Early cognitive screening predicts stroke outcome

                                          Early cognitive screening predicts stroke outcome

                                          October 2018

                                          ISD investigators in collaboration with researchers from France found that MoCA, a brief cognitive test, when taken within a week after stroke predicts the risk of cognitive impairment, functional impairment and mortality up to 3 years later. The findings inform clinical practice by highlighting the need of early cognitive screening after stroke...


                                          Role of Monocyte Chemo-attractant Protein-1 in stroke

                                          Role of Monocyte Chemo-attractant Protein-1 in stroke

                                          September 2018

                                          Using a Mendelian Randomization approach and data from >800.000 individuals ISD investigators showed that genetic predisposition to higher levels of the inflammatory cytokine MCP-1 is associated with a higher risk of stroke, in particular large artery stroke and cardioembolic stroke. These findings inform the planning of future clinical trials... 


                                          SyNergy-Logo

                                          4 Clusters of Excellence accepted

                                          September 2018

                                          The first funding decisions in the context of the Excellence Strategy have been announced. Four Clusters of Excellence including the Munich Cluster for Systems Neurology (SyNergy) submitted by LMU and TUM were successful and will receive funding from 2019 on...


                                          White matter alterations

                                          White matter alterations precede symptom onset in Alzheimer’s dementia

                                          September 2018

                                          Ewers and his team found the evolution of white matter alterations to start in callosal fibers already 10 years before estimated symptoms onset in familial Alzheimer’s disease...


                                          Chenchen Pan

                                          Chinese government award for ISD Member

                                          August 2018

                                          Chenchen Pan from Ali Ertuerk's group received the Chinese government award for outstanding self-finance students abroad. Established by the China Scholarship Council in 2003 the award is considered the highest recognition given by the Chinese government to graduate students abroad who do not receive financial support from the Chinese government...


                                          ERC Starting Grant for Arthur Liesz

                                          ERC Starting Grant for Arthur Liesz

                                          July 2018

                                          A prestigious ERC Starting Grant was awarded to the ISD researcher Arthur Liesz for the project „RecoverInFlame“. The 1.5M € award by the European Research Council (ERC) will support the Liesz lab to investigate inflammatory mechanisms in the recovery after acute stroke...


                                          Dr. Stefan Roth and Dr. Arthur Liesz

                                          Rolf-Becker Prize 2018 awarded to ISD scientists

                                          July 2018

                                          Stefan Roth and Dr. Arthur Liesz were awarded with the "Rolf-Becker"-Prize for one of the best scientific outputs in 2017/18 by the Medical Faculty of LMU Munich and the foundation "Rufzeichen Gesundheit!" Baierbrunn. They received this prestigious award for their recent work published in Science Translational Medicine...


                                          Common genetic basis of common brain disease

                                          Common genetic basis of common brain disease

                                          May 2018

                                          A large scale genetic study on major brain diseases including stroke and Alzheimer's disease revealed shared genetic influences between multiple brain disorders and relevant phenotypes, including cognitive measures. The results highlight the value of heritability-based methods in understanding the ethiology of neurological and psychiatric disorders. ISD investigators were on the steering committee of this work which was published in Science...


                                          CRC 1123

                                          Second funding period of SFB1123 approved

                                          May 2018

                                          The Collaborative Research Center SFB1123 „Atherosclerosis – Mechanisms and Networks of Novel Therapeutic Targets" has been approved a second funding period. The ISD contributes to the LMU led network with two projects, headed by Martin Dichgans/Yaw Asare (project B5) and Jürgen Bernhagen (project A3), as well as flanking project C1 (Arthur Liesz)...


                                          ESO European Stroke Organization

                                          Young Investigator Award 2018 by ESOC for Steffen Tiedt

                                          May 2018

                                          Steffen Tiedt, a clinician scientist at the ISD has been awarded the Young Investigator Award 2018 by the European Stroke Organisation (ESO) for his work on serum Neurofilament Light as a marker for neuroaxonal injury after stroke...


                                          MIF protects from complications after cardiac surgery

                                          MIF protects from complications after cardiac surgery

                                          May 2018

                                          Complex heart surgery may lead to organ dysfunction such as acute kidney injury (AKI) or ischemic stroke. A researcher team led by Aachen University and the Bernhagen lab found that patients with high blood levels of the cytokine MIF had a reduced risk of developing AKI. The study is published in this week’s issue of Sci Transl Med...


                                          HTRA1 loss-of-function in CADASIL

                                          HTRA1 loss-of-function in CADASIL

                                          May 2018

                                          Isolation of CADASIL patient brain vessels in combination with proteome analysis identified loss of HTRA1 proteolytic function as a critical step in the development of disease pathology providing novel insights into the molecular mechanisms of cerebral small vessel diseases....


                                          A novel link between the chemokine MIF and B lymphocytes in atherosclerosis

                                          A novel link between the chemokine MIF and B lymphocytes in atherosclerosis

                                          Apr 2018

                                          The Bernhagen lab at ISD together with collaborating labs uncovered a previously unrecognized connection between the atherogenic chemokine-like cytokine MIF and B cell function in atherosclerosis...


                                          ESO European Stroke Organization

                                          Action Plan for Stroke in Europe 2018-2030

                                          Mar 2018

                                          Munich, March 21-23, the European Stroke Organisation (ESO) in collaboration with the Stroke Alliance for Europe (SAFE) convened leading experts in stroke research and care to an international workshop targeted at identifying current challenges in the prevention and treatment of stroke, set the goals for the next decade...

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                                          Institute for Stroke and Dementia Research (ISD)
                                          University Hospital, LMU Munich

                                          Director: Prof. Dr. med. Martin Dichgans

                                          Feodor-Lynen-Straße 17

                                          81377 Munich, Germany

                                          Phone: +49 (0)89 4400 46019
                                          www.isd-research.de
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