News
First LEDUCQ Network Meeting in NY City
Hertie Network of Excellence in Clinical Neuroscience approved for prolongation
ERA-NET Collaborative grants on cerebrovascular diseases (CVD)
3D spatial-omics technology to tackle complicated diseases.
Martin Dichgans among „Highly Cited Researchers 2022”
CD8+ T cells induce IFN-responsive oligodendrocytes & microglia in white matter aging
2nd funding period for ImmunoStroke consortium granted
Stroke genetics informs drug discovery and risk prediction across ancestries
Leducq grant on Brain Endothelium in Cerebral Small Vessel Disease
ISD Research Retreat
July 2022 – ISD research teams met for the annual scientific retreat to present their projects and discuss the science. At the heart of this meeting were presentations from Ph.D. students, including an evening poster session, a guest talk by Nobel price laureate Reinhard Genzel, and focused workshops. The meeting further served as an opportunity to familiarize people with the medium- and long-term strategy of ISD.
Complicated Carotid Artery Plaques and Risk of Recurrent Ischemic Stroke or TIA
Brain connectivity is associated with tau deposition in 4-repeat tauopathies
Leducq grant on circadian mechanisms in stroke
Role of HTRA1 in brain white matter hyperintensities
Interneurons trigger cortical spreading depolarizations (CSDs)
Role of complement component C4 in age-related white matter injury
de Leon Senior Scientist Prize for Michael Ewers
Common KLOTHO SNP protects against Tau pathology
Life’s simple 7 and incident dementia risk
Genetic downregulation of IL-6 signaling leads to a favourable cardiometabolic profile
March 2021 – Drugs targeting IL6 signaling have been approved for autoimmune diseases but the repurposing potential for other indications remains unknown. ISD researchers developed a genetic score predicting IL6 signaling activity over lifetime. In a phenome-wide association study they found genetically downregulated IL6 signaling to be associated with a favourable cardiometabolic profile including a lower risk of coronary artery disease and diabetes, and an increase in HDL cholesterol levels. Their results support repurposing of IL6R blockade as a strategy for lowering vascular risk...
AIM2-inflammasome signaling cascade causes post-stroke immunosuppression and secondary infections
First International Stroke-Immunology Conference | Online
White matter aging drives microglial diversity