Funded Publications

YEAR

Publication

Funding

2020

Gill D, Georgakis MK, Zuber V, Karhunen V, Burgess S, Malik R, Dichgans M. Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk: Mendelian Randomization Analysis. J Am Heart Assoc. 2020 Jul 21;9(14):e016773. doi: 10.1161/JAHA.120.016773. Epub 2020 Jul 4. 

SVDs@target

2020

Georgakis MK, Gill D, Malik R, Protogerou AD, Webb AJS, Dichgans M. Genetically Predicted Blood Pressure Across the Lifespan: Differential Effects of Mean and Pulse Pressure on Stroke Risk. Hypertension. 2020 Jul 6:HYPERTENSIONAHA12015136. doi: 10.1161/HYPERTENSIONAHA.120.15136. Epub ahead of print. 

SVDs@target

2020

Georgakis MK, Gill D, Webb AJS, Evangelou E, Elliott P, Sudlow CLM, Dehghan A, Malik R, Tzoulaki I, Dichgans M. Genetically determined blood pressure, antihypertensive drug classes, and risk of stroke subtypes. Neurology. 2020 Jul 1:10.1212/WNL.0000000000009814. doi: 10.1212/WNL.0000000000009814. Epub ahead of print. 

SVDs@target

2020

Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RT, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M.
Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability.
Circ Res. 2020 Jun 17. Epub ahead of print. 

SVDs@target

2020

Georgakis MK, Malik R, Gill D, Franceschini N, Sudlow CLM, Dichgans M; INVENT Consortium,CHARGE Inflammation Working Group.
Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes: A Mendelian Randomization Study.
Circ Genom Precis Med. 2020 Jun;13(3):e002872.

SVDs@target

2020

Georgakis MK, Malik R, Anderson CD, Parhofer KG, Hopewell JC, Dichgans M. 
Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol.
Brain. 2020 Feb 1;143(2):597-610

SVDs@target

2019

Abraham G, Malik R, Yonova-Doing E, Salim A, Wang T, Danesh J, Butterworth AS, Howson JMM, Inouye M, Dichgans M.
Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke.
Nat Commun. 2019 Dec 20;10(1):5819. 

SVDs@target

2019

Gladman JT, Corriveau RA, Debette S, Dichgans M, Greenberg SM, Sachdev PS, Wardlaw JM, Biessels GJ.
Vascular contributions to cognitive impairment and dementia: Research consortia that focus on etiology and treatable targets to lessen the burden of dementia worldwide.
Alzheimers Dement (N Y). 2019 Nov 19;5:789-796. 

SVDs@target

2019

Ter Telgte A, Wiegertjes K, Gesierich B, Marques JP, Huebner M, de Klerk JJ, Schreuder FHBM, Araque Caballero MA, Kuijf HJ, Norris DG, Klijn CJM, Dichgans M, Tuladhar AM, Duering M, de Leeuw FE.
Contribution of acute infarcts to cerebral small vessel disease progression.
Ann Neurol. 2019 Oct;86(4):582-592., Erratum in: Ann Neurol. 2019 Nov;86(5):807.

SVDs@target

2019

Prestel M, Prell-Schicker C, Webb T, Malik R, Lindner B, Ziesch N, Rex-Haffner M, Röh S, Viturawong T, Lehm M, Mokry M, den Ruijter H, Haitjema S, Asare Y, Söllner F, Najafabadi MG, Aherrahrou R, Civelek M, Samani NJ, Mann M, Haffner C, Dichgans M.
The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1.
Stroke. 2019 Oct;50(10):2651-2660. 

SVDs@target

2019

Georgakis MK, Malik R, Björkbacka H, Pana TA, Demissie S, Ayers C, Elhadad MA, Fornage M, Beiser AS, Benjamin EJ, Boekholdt SM, Engström G, Herder C, Hoogeveen RC, Koenig W, Melander O, Orho-Melander M, Schiopu A, Söderholm M, Wareham N, Ballantyne CM, Peters A, Seshadri S, Myint PK, Nilsson J, de Lemos JA, Dichgans M.
Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: Meta-Analysis of Population-Based Studies Involving 17 180 Individuals.
Circ Res. 2019 Sep 27;125(8):773-782. Erratum in: Circ Res. 2020 Jan 3;126(1):e9. 

SVDs@target

2019

Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, Wardlaw J, Greenberg S, Friberg L, Norrving B, Rowe B, Joanette Y, Hacke W, Kuller L, Dichgans M, Endres M, Khachaturian ZS.
Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto.
Int J Stroke. 2019 Sep 22:1747493019871915.

SVDs@target

2019

Thrippleton MJ, Backes WH, Sourbron S, Ingrisch M, van Osch MJP, Dichgans M, Fazekas F, Ropele S, Frayne R, van Oostenbrugge RJ, Smith EE, Wardlaw JM.
Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations.
Alzheimers Dement. 2019 Jun;15(6):840-858. 

SVDs@target

2019

Dichgans M, Pulit SL, Rosand J.
Stroke genetics: discovery, biology, and clinical applications.
Lancet Neurol. 2019 Jun;18(6):587-599. 

SVDs@target

2019

Sun D, Tiedt S, Yu B, Jian X, Gottesman RF, Mosley TH, Boerwinkle E, Dichgans M, Fornage M.
A prospective study of serum metabolites and risk of ischemic stroke.
Neurology. 2019 Apr 16;92(16):e1890-e1898. 

SVDs@target

2019

Georgakis MK, Duering M, Wardlaw JM, Dichgans M.
WMH and long-term outcomes in ischemic stroke: A systematic review and meta-analysis.
Neurology. 2019 Mar 19;92(12):e1298-e1308. 

SVDs@target

2019

Dichgans M.
Dementia risk after transient ischaemic attack and stroke. 
Lancet Neurol. 2019 Mar;18(3):223-225. 

SVDs@target

2019

Wollenweber FA, Opherk C, Zedde M, Catak C, Malik R, Duering M, Konieczny MJ, Pascarella R, Samões R, Correia M, Martí-Fàbregas J, Linn J, Dichgans M.
Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy.
Neurology. 2019 Feb 19;92(8):e792-e801.

SVDs@target

2019

Georgakis MK, Gill D, Rannikmäe K, Traylor M, Anderson CD, Lee JM, Kamatani Y, Hopewell JC, Worrall BB, Bernhagen J, Sudlow CLM, Malik R, Dichgans M.
Genetically Determined Levels of Circulating Cytokines and Risk of Stroke.
Circulation. 2019 Jan 8;139(2):256-268. 

SVDs@target

2019

Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, Mazoyer B, Zhu YC, Kaffashian S, Schilling S, Beecham GW, Montine TJ, Schellenberg GD, Kjartansson O, Guðnason V, Knopman DS, Griswold ME, Windham BG, Gottesman RF, Mosley TH, Schmidt R, Saba Y, Schmidt H, Takeuchi F, Yamaguchi S, Nabika T, Kato N, Rajan KB, Aggarwal NT, De Jager PL, Evans DA, Psaty BM, Rotter JI, Rice K, Lopez OL, Liao J, Chen C, Cheng CY, Wong TY, Ikram MK, van der Lee SJ, Amin N, Chouraki V, DeStefano AL, Aparicio HJ, Romero JR, Maillard P, DeCarli C, Wardlaw JM, Hernández MDCV, Luciano M, Liewald D, Deary IJ, Starr JM, Bastin ME, Muñoz Maniega S, Slagboom PE, Beekman M, Deelen J, Uh HW, Lemmens R, Brodaty H, Wright MJ, Ames D, Boncoraglio GB, Hopewell JC, Beecham AH, Blanton SH, Wright CB, Sacco RL, Wen W, Thalamuthu A, Armstrong NJ, Chong E, Schofield PR, Kwok JB, van der Grond J, Stott DJ, Ford I, Jukema JW, Vernooij MW, Hofman A, Uitterlinden AG, van der Lugt A, Wittfeld K, Grabe HJ, Hosten N, von Sarnowski B, Völker U, Levi C, Jimenez-Conde J, Sharma P, Sudlow CLM, Rosand J, Woo D, Cole JW, Meschia JF, Slowik A, Thijs V, Lindgren A, Melander O, Grewal RP, Rundek T, Rexrode K, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Wong Q, Mitchell BD, Rich SS, McArdle PF, Geerlings MI, van der Graaf Y, de Bakker PIW, Asselbergs FW, Srikanth V, Thomson R, McWhirter R, Moran C, Callisaya M, Phan T, Rutten-Jacobs LCA, Bevan S, Tzourio C, Mather KA, Sachdev PS, van Duijn CM, Worrall BB, Dichgans M, Kittner SJ, Markus HS, Ikram MA, Fornage M, Launer LJ, Seshadri S, Longstreth WT Jr, Debette S; Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.
Neurology. 2019 Jan 16;92(5):e486–503. 

SVDs@target

2019

Gill D, Georgakis MK, Koskeridis F, Jiang L, Feng Q, Wei WQ, Theodoratou E, Elliott P, Denny JC, Malik R, Evangelou E, Dehghan A, Dichgans M, Tzoulaki I.
Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects.
Circulation. 2019 Jul 23;140(4):270-279. 

SVDs@target

2019

Iadecola C, Duering M, Hachinski V, Joutel A, Pendlebury ST, Schneider JA, Dichgans M.
Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel.
J Am Coll Cardiol. 2019 Jul 2;73(25):3326-3344.

SVDs@target

2019

Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, Wardlaw J, Greenberg S, Friberg L, Norrving B, Rowe B, Joanette Y, Hacke W, Kuller L, Dichgans M, Endres M, Khachaturian ZS.
Preventing dementia by preventing stroke: The Berlin Manifesto.
Alzheimers Dement. 2019 Jul;15(7):961-984. 

SVDs@target

2018

Duering M, Finsterwalder S, Baykara E, Tuladhar AM, Gesierich B, Konieczny MJ, Malik R, Franzmeier N, Ewers M, Jouvent E, Biessels GJ, Schmidt R, de Leeuw FE, Pasternak O, Dichgans M.
Free water determines diffusion alterations and clinical status in cerebral small vessel disease.
Alzheimers Dement. 2018 Jun;14(6):764-774. 

SVDs@target

2018

Malik R, Dichgans M.
Challenges and opportunities in stroke genetics.
Cardiovasc Res. 2018 Jul 15;114(9):1226-1240. doi: 10

SVDs@target

2018

Bernhardt J, Zorowitz RD, Becker KJ, Keller E, Saposnik G, Strbian D, Dichgans M, Woo D, Reeves M, Thrift A, Kidwell CS, Olivot JM, Goyal M, Pierot L, Bennett DA, Howard G, Ford GA, Goldstein LB, Planas AM, Yenari MA, Greenberg SM, Pantoni L, Amin-Hanjani S, Tymianski M.
Advances in Stroke 2017.
Stroke. 2018 May;49(5):e174-e199. d

SVDs@target

2018

Zellner A, Scharrer E, Arzberger T, Oka C, Domenga-Denier V, Joutel A, Lichtenthaler SF, Müller SA, Dichgans M, Haffner C.
CADASIL brain vessels show a HTRA1 loss-of-function profile.
Acta Neuropathol. 2018 Jul;136(1):111-125. 

SVDs@target

2018

Rutten-Jacobs LCA, Tozer DJ, Duering M, Malik R, Dichgans M, Markus HS, Traylor M.
Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia.
Stroke. 2018 Jun;49(6):1340-1347. 

SVDs@target

2018

Tiedt S, Duering M, Barro C, Kaya AG, Boeck J, Bode FJ, Klein M, Dorn F, Gesierich B, Kellert L, Ertl-Wagner B, Goertler MW, Petzold GC, Kuhle J, Wollenweber FA, Peters N, Dichgans M. 
Serum neurofilament light: A biomarker of neuroaxonal injury after ischemic stroke.
Neurology. 2018 Oct 2;91(14):e1338-e1347. 

SVDs@target

2018

Zietemann V, Georgakis MK, Dondaine T, Müller C, Mendyk AM, Kopczak A, Hénon H, Bombois S, Wollenweber FA, Bordet R, Dichgans M.
Early MoCA predicts long-term cognitive and functional outcome and mortality after stroke.
Neurology. 2018 Nov 13;91(20):e1838-e1850. 

SVDs@target

2018

Rutten-Jacobs LC, Larsson SC, Malik R, Rannikmäe K; MEGASTROKE consortium; International Stroke Genetics Consortium, Sudlow CL, Dichgans M, Markus HS, Traylor M.
Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants.
BMJ. 2018 Oct 24;363:k4168. 

SVDs@target

2018

Tiedt S, Dichgans M.
Role of Non-Coding RNAs in Stroke.
Stroke. 2018 Dec;49(12):3098-3106. 

SVDs@target

2017

Dichgans M, Leys D.
Vascular Cognitive Impairment.
Circ Res. 2017 Feb 3;120(3):573-591.

SVDs@target

2017

Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, Yet I, Spector TD, Bell JT, Hannon E, Mill J, Chauhan G, Debette S, Bis JC, Longstreth WT Jr, Ikram MA, Launer LJ, Seshadri S; METASTROKE, UK Young Lacunar DNA Study, NINDS Stroke Genetics Network, Neurology Working Group of the CHARGE Consortium, Hamilton-Bruce MA, Jimenez-Conde J, Cole JW, Schmidt R, Słowik A, Lemmens R, Lindgren A, Melander O, Grewal RP, Sacco RL, Rundek T, Rexrode K, Arnett DK, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Pulit SL, Wong Q, Rich SS, de Bakker PI, McArdle PF, Woo D, Anderson CD, Xu H, Heitsch L, Fornage M, Jern C, Stefansson K, Thorsteinsdottir U, Gretarsdottir S, Lewis CM, Sharma P, Sudlow CL, Rothwell PM, Boncoraglio GB, Thijs V, Levi C, Meschia JF, Rosand J, Kittner SJ, Mitchell BD, Dichgans M, Worrall BB, Markus HS; International Stroke Genetics Consortium.
Genetic variation at 16q24.2 is associated with small vessel stroke. Version 2.
Ann Neurol. 2017 Mar;81(3):383-394.

SVDs@target

2017

Tiedt S, Prestel M, Malik R, Schieferdecker N, Duering M, Kautzky V, Stoycheva I, Böck J, Northoff BH, Klein M, Dorn F, Krohn K, Teupser D, Liesz A, Plesnila N, Holdt LM, Dichgans M.
RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke.
Circ Res. 2017 Sep 29;121(8):970-980.

SVDs@target

2017

Rannikmäe K, Sivakumaran V, Millar H, Malik R, Anderson CD, Chong M, Dave T, Falcone GJ, Fernandez-Cadenas I, Jimenez-Conde J, Lindgren A, Montaner J, O'Donnell M, Paré G, Radmanesh F, Rost NS, Slowik A, Söderholm M, Traylor M, Pulit SL, Seshadri S, Worrall BB, Woo D, Markus HS, Mitchell BD, Dichgans M, Rosand J, Sudlow CLM; Stroke Genetics Network (SiGN), METASTROKE Collaboration, and International Stroke Genetics Consortium (ISGC).
COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.
Neurology. 2017 Oct 24;89(17):1829-1839.

SVDs@target

2017

Zietemann V, Kopczak A, Müller C, Wollenweber FA, Dichgans M.
Validation of the Telephone Interview of Cognitive Status and Telephone Montreal Cognitive Assessment Against Detailed Cognitive Testing and Clinical Diagnosis of Mild Cognitive Impairment After Stroke. Stroke. 2017 Nov;48(11):2952-2957.

SVDs@target

2016

SVDs@target

2016

SVDs@target

2016

Dichgans M, Planas AM, Biessels GJ, van der Worp B, Sudlow C, Norrving B, Lees K, Mattle HP.
Third European Stroke Science Workshop.
Stroke. 2016 Jul;47(7):e178-86.

SVDs@target