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Junior Research Groups

The risk of early recurrent events after stroke remains high, especially in patients with atherosclerosis.

August 2024 –  Using a novel mouse model, ISD researchers showed stroke activates the AIM2 inflammasome in atherosclerotic plaques via increased circulating cell-free DNA, causing inflammation, plaque destabilization, and recurrent stroke. Neutrophil NETosis was identified as the main source of cell-free DNA. Neutralizing cell-free DNA or inhibiting inflammasome activation reduced stroke recurrence, highlighting new therapeutic targets to prevent early recurrent events >>

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DNA-sensing inflammasomes cause recurrent atherosclerotic stroke

8 Aug 2024

Using a novel experimental model, ISD researchers showed that stroke activates the AIM2 inflammasome in atherosclerotic plaques via increased circulating cell-free DNA, causing inflammation, plaque…

Innate immune memory after stroke mediates secondary comorbidities. 

22 Jul 2024

ISD researchers hypothesized in a newly published study that the high rate of comorbidities that develop after a stroke could have a common immunological cause. A Myeloid innate immune memory was…

Rational correction of disease-causing mutations in HTRA1

17 Jul 2024

Rare mutations in HTRA1 cause cerebral vasculopathy and stroke. Using in vitro, in silico and in vivo analyses, the Dichgans lab in collaboration with colleagues from Duisburg established…

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ISD Research Retreat

4 Jul 2024

ISD research teams gathered for the annual scientific retreat to present their projects and discuss science. The meeting included presentations from Ph.D. students, an evening poster session, invited…

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International Review by the ISD Scientific Advisory Board

20 Jun 2024

Every two years, an international committee of scientific advisors evaluates ISD's research activities and makes recommendations for future direction. The first day of the meeting was dedicated to an…

Innate immune memory after stroke mediates secondary comorbidities. 

22 Jul 2024

ISD researchers hypothesized in a newly published study that the high rate of comorbidities that develop after a stroke could have a common immunological cause. A Myeloid innate immune memory was…

Rational correction of disease-causing mutations in HTRA1

17 Jul 2024

Rare mutations in HTRA1 cause cerebral vasculopathy and stroke. Using in vitro, in silico and in vivo analyses, the Dichgans lab in collaboration with colleagues from Duisburg established…

Rare and common HTRA1 variants affect stroke risk via two independent mechanisms

5 May 2024

Combining genetic analyses in large international biobanks with experimental studies on human cells, ISD investigators found that rare HTRA1 variants affect vascular risk via a loss of enzymatic…

International Review by the ISD Scientific Advisory Board

20 Jun 2024

Every two years, an international committee of scientific advisors evaluates ISD's research activities and makes recommendations for future direction. The first day of the meeting was dedicated to an…

October 15-17: 9th ICAA Conference in Munich

July 2024 – ISD is co-organizing the 9th Interational Conference on Cerebral Amyloid Angiopathy located at the Kardinal Wendel Haus next to the English Garden in Munich. Experts in the field will present the latest developments in CAA research ranging from basic research to studies in humans. To take part sign up now here >>

ISD Research Retreat

July 2024 – ISD research teams gathered for the annual scientific retreat to present their projects and discuss science. The meeting included presentations from Ph.D. students, an evening poster session, invited speaker talks, and a three minute thesis competition. The meeting further served as an opportunity to familiarize people with the medium- and long-term strategy of ISD.

Junior Research Groups